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Volume 28, Number 7—July 2022

Natural History of and Dynamic Changes in Clinical Manifestation, Serology, and Treatment of Brucellosis, China

Hongyu Wang1, Hongyan Liu1, Qiran Zhang1, Xiaobo Lu1, Dan Li1, Haocheng Zhang1, Yan A. Wang, Rongjiong Zheng, Yi Zhang, Zhangfan Fu, Ke Lin, Chao Qiu, Yan O. Wang, Ye GuComments to Author , Jingwen AiComments to Author , and Wenhong ZhangComments to Author 
Author affiliations: National Medical Center for Infectious Disease, National Clinical Research Center for Aging and Medicine, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, China (H. Wang, Q. Zhang, H. Zhang, Y. Zhang, Z. Fu, K. Lin, C. Qiu, J. Ai, W. Zhang); The Sixth People’s Hospital of Shenyang, Shenyang, China (H. Liu, D. Li, Y.A. Wang, Y.O. Wang, Y. Gu); Emergency Treatment and Innovation Center of Public Health Emergencies, Shenyang (H. Liu, D. Li, Y.A. Wang, Y.O. Wang, Y. Gu); Center for Infectious Diseases, the First Affiliated Hospital of Xinjiang Medical University, Wulumuqi, China (X. Lu, R. Zheng); Key Laboratory of Medical Molecular Virology (MOE/MOH), Shanghai Medical College, Fudan University, Shanghai (W. Zhang)

Main Article

Table 1

Demographic characteristics of brucellosis case-patients at enrollment in study of natural history and dynamic changes in clinical signs, serology, and treatment of brucellosis, China, 2014–2020*

Characteristic Case-patients, n = 3,411
Median age, y (IQR)† 48.0 (35.8–57.0)
<20 143 (4.4)
20–40 933 (29.0)
40–60 1,629 (50.6)
515 (16.0)
M 2,452 (73.9)
867 (26.1%)
Han 1,818 (53.6)
1,572 (46.4)
Farmer 2,591 (76.9)
Herdsman 185 (5.5)
Veterinarian 33 (1.0)
560 (16.6)
Contact history
Exposure to suspicious animals 2,066 (60.6)
Contact with brucellosis patients 1,686 (49.4)
Residence in endemic area 1,129 (33.1)
Exposure to Brucella
58 (1.7)
Diagnostic test#
Brucella culture 424 (23.2)
Antibody SAT
3,351 (99.1)
1:50 9 (0.4)
1:100 797 (35.2)
1:200 643 (28.4)
>1:400 815 (36.0)

*Values are no. (%) except as indicated. IQR, interquartile range; SAT, serum agglutination test. †Information on age was available for 3,220 participants. ‡Information on sex was available for 3,319 participants. §Information on nationality was available for 3,390 participants. ¶Information on occupation was available for 3,369 participants. #A total of 1,827 participants received Brucella culture, and 3,381 received SAT. **Among 3,381 participants tested by SAT, 2,264 had detailed positive titer information.

Main Article

1These authors contributed equally to this article.

Page created: May 12, 2022
Page updated: June 21, 2022
Page reviewed: June 21, 2022
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