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Volume 28, Number 8—August 2022
Dispatch

Zoonotic Threat of G4 Genotype Eurasian Avian-Like Swine Influenza A(H1N1) Viruses, China, 2020

Min Gu1, Kaibiao Chen1, Zhichuang Ge, Jun Jiao, Tianyu Cai, Suhan Liu, Xiaoquan Wang, Xinan Jiao, Daxin Peng, and Xiufan LiuComments to Author 
Author affiliations: Yangzhou University, Yangzhou, China (M. Gu, K. Chen, Z. Ge, J. Jiao, T. Cai, S. Liu, X. Wang, X. Jiao, D. Peng, X. Liu); Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou (M. Gu, X. Wang, X. Jiao, D. Peng, X. Liu)

Main Article

Figure 1

Receptor-binding property of 2 G4 Eurasian avian-like influenza A(H1N1) swine isolates from pigs in China. A) The control virus A/mallard/Huadong/S/2005(H5N1) (HDS05) showed an absolute preference for avian-type SAα-2,3Gal. B) The control virus A/Jiangsu/202/2010(H3N2) (JS202) displayed double affinities to both human-type SAα-2,6Gal and avian-type SAα-2,3Gal, but with an overt bias toward SAα-2,6Gal. C) The tested virus A/swine/Jiangsu/HD11/2020(H1N1) (HD11) resembled the human-origin JS202 to possess an obviously advantageous avidity for SAα-2,6Gal over SAα-2,3Gal. D) The tested virus A/swine/Anhui/HD21/2020(H1N1) (HD21) exhibited comparable binding capacity to SAα-2,6Gal and SAα-2,3Gal without apparent preference. The solid-phase direct binding ELISA assay with the synthetic sialyl glycopolymers containing either 3′SLN-PAA and 6′SLN-PAA was applied to estimate the virus binding to avian-type SAα-2,3Gal and human-type SAα-2,6Gal, respectively. The data shown are representative of 3 independent binding experiments. SLN, sialyl-N-acetyllactosamine.

Figure 1. Receptor-binding property of 2 G4 Eurasian avian-like influenza A(H1N1) swine isolates from pigs in China. A) The control virus A/mallard/Huadong/S/2005(H5N1) (HDS05) showed an absolute preference for avian-type SAα-2,3Gal. B) The control virus A/Jiangsu/202/2010(H3N2) (JS202) displayed double affinities to both human-type SAα-2,6Gal and avian-type SAα-2,3Gal, but with an overt bias toward SAα-2,6Gal. C) The tested virus A/swine/Jiangsu/HD11/2020(H1N1) (HD11) resembled the human-origin JS202 to possess an obviously advantageous avidity for SAα-2,6Gal over SAα-2,3Gal. D) The tested virus A/swine/Anhui/HD21/2020(H1N1) (HD21) exhibited comparable binding capacity to SAα-2,6Gal and SAα-2,3Gal without apparent preference. The solid-phase direct binding ELISA assay with the synthetic sialyl glycopolymers containing either 3′SLN-PAA and 6′SLN-PAA was applied to estimate the virus binding to avian-type SAα-2,3Gal and human-type SAα-2,6Gal, respectively. The data shown are representative of 3 independent binding experiments. SLN, sialyl-N-acetyllactosamine.

Main Article

1These authors contributed equally to this article.

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Page updated: July 20, 2022
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