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Volume 28, Number 8—August 2022

Dispatch

Child Melioidosis Deaths Caused by Burkholderia pseudomallei–Contaminated Borehole Water, Vietnam, 2019

Quyen T.L. Tran, Phuc H. Phan, Linh N.H. Bui, Ha T.V. Bui, Ngoc T.B. Hoang, Dien M. Tran, and Trung T. TrinhComments to Author 
Author affiliations: Vietnam National University, Hanoi, Vietnam (Q.T.L. Tran, L.N.H. Bui, H.T.V. Bui, T.T. Trinh); Vietnam National Children’s Hospital, Hanoi (P.H. Phan, N.T.B. Hoang, D.M. Tran)

Main Article

Table 1

Demographic and clinical characteristics and corresponding isolates from 3 children who died of melioidosis caused by Burkholderia pseudomallei–contaminated borehole water, Vietnam, 2019*

Characteristics Case 1
 Case 2
 Case 3
Age, y/sex
 7/F
5/M
1/M
Date
Symptom onset Apr 6 Oct 27 Nov 10
Hospital admission Apr 9 Oct 28 Nov 11
Death
 Apr 9
Oct 31
Nov 16
Signs and symptoms High fever, abdominal pain, vomiting, diarrhea with mucous, tachycardia, and cyanosis High fever, abdominal pain, vomiting, tachypnea, and tachycardia High fever, poor appetite, mild pitting edema in the feet and hands, tachypnea, and tachycardia
Underlying disease
 Not detectable
Not detectable
Not detectable
Microbiology
Blood culture ND B. pseudomallei–positive B. pseudomallei–positive
Sequence type ND 541 541
Other sample cultures
 ND
ND
ND
Antimicrobial drug treatment
 Cefoperazone in the first day; then efoperazone and amikacin on subsequent days
Ceftriaxone, tobramycin, and metronidazole in the first day; then meropenem and levofloxacin on subsequent days
Ceftazidime in the first 2 days; meropenem in the last 3 days
Imaging at admission
Chest radiograph NA No abnormalities noted No abnormalities noted
Abdominal radiograph NA No abnormalities noted NA
Abdominal ultrasound
 NA
No abnormalities noted
NA
Laboratory findings Day 1
 Day 2
Day 1
 Day 2
Day 1
 Day 3
 Day 4
 Day 5
WBC, × 109 cells/L 0.6 0.7 25.2 0.35 10.8 7.5 1.35 1.06
Neutrophils, × 109 cells/L NA 0.12 22.8 0.05 8.4 4.0 0.76 0.38
Lymphocytes, × 109 cells/L NA 0.48 1.07 0.29 1.52 3.07 0.50 0.55
Platelets, × 109 cells/L 47 36 272 29 264 172 67 32
Urea, mmol/L 8.9 9.9 NA 9.8 2.2 1.4 3.7 4.1
Creatinine, µmol/L 91 123 NA 124 45 33 55 71
AST, U/L 571 713 NA 602 23 59 185 269
ALT, U/L 226 258 NA 166 10 40 94 73
CRP, mg/L 124 NA 26 148 57 NA 209 158
PCT, ng/mL NA >100 NA >100 9 43 NA NA

*Data were collected from the St. Paul Hospital and Vietnam National Children’s Hospital, except for the laboratory findings for case 1, which were retrieved from the child’s local hospital. ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; NA, not available; ND, not done; PCT, procalcitonin; WBC, white blood cell count.

Main Article

Page created: June 13, 2022
Page updated: July 20, 2022
Page reviewed: July 20, 2022
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