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Volume 28, Number 9—September 2022
Research Letter

Trichodysplasia Spinulosa Polyomavirus Endothelial Infection, California, USA

Lauren Lawrence1Comments to Author , Aihui Wang, Gregory Charville, Angus Toland, Benjamin Pinsky, Yasodha Natkunam, Sheren Younes, Henning Stehr, and Dita Gratzinger
Author affiliations: Stanford Healthcare, Palo Alto, California, USA (L. Lawrence, A. Toland); Stanford University School of Medicine, Stanford, California, USA (A. Wang, G. Charville, B. Pinsky, Y. Natkunam, S. Younes, H. Stehr, D. Gratzinger)

Main Article

Table

Case summaries of 3 patients with trichodysplasia spinulosa polyomavirus endothelial infection, California, USA*

Case no. Histopathologic diagnosis Immunosuppression Localization of RNA Clinical manifestation
1 Metastatic pulmonary adenocarcinoma
involving brain		 Dexamethasone (4 mg) leading up to resection; rituximab/bendamustine treatment completed 18 mo before resection for follicular lymphoma Endothelium Ground level fall, confusion, forgetfulness, ambulatory instability
2 Anaplastic meningioma Dexamethasone (2 mg × 10 d, then 1 mg × 2 d) leading up to resection Endothelium Confusion, headaches, cheek numbness, ambulatory instability
3 Metastatic perivascular epithelial cell tumor involving liver Gemcitabine/docetaxel completed 1 mo before resection; prednisone (8 mg orally 2×/d) for 1 mo leading up to resection Endothelium Abdominal pain, fever, vomiting, hypoxia

Main Article

1Current affiliation: Guardant Health, Redwood City, California, USA.

Page created: July 07, 2022
Page updated: August 19, 2022
Page reviewed: August 19, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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