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Volume 28, Number 9—September 2022
Research Letter

Trichodysplasia Spinulosa Polyomavirus Endothelial Infection, California, USA

Lauren Lawrence1Comments to Author , Aihui Wang, Gregory Charville, Angus Toland, Benjamin Pinsky, Yasodha Natkunam, Sheren Younes, Henning Stehr, and Dita Gratzinger
Author affiliations: Stanford Healthcare, Palo Alto, California, USA (L. Lawrence, A. Toland); Stanford University School of Medicine, Stanford, California, USA (A. Wang, G. Charville, B. Pinsky, Y. Natkunam, S. Younes, H. Stehr, D. Gratzinger)

Main Article


Case summaries of 3 patients with trichodysplasia spinulosa polyomavirus endothelial infection, California, USA*

Case no. Histopathologic diagnosis Immunosuppression Localization of RNA Clinical manifestation
1 Metastatic pulmonary adenocarcinoma
involving brain
Dexamethasone (4 mg) leading up to resection; rituximab/bendamustine treatment completed 18 mo before resection for follicular lymphoma Endothelium Ground level fall, confusion, forgetfulness, ambulatory instability
2 Anaplastic meningioma Dexamethasone (2 mg × 10 d, then 1 mg × 2 d) leading up to resection Endothelium Confusion, headaches, cheek numbness, ambulatory instability
3 Metastatic perivascular epithelial cell tumor involving liver Gemcitabine/docetaxel completed 1 mo before resection; prednisone (8 mg orally 2×/d) for 1 mo leading up to resection Endothelium Abdominal pain, fever, vomiting, hypoxia

Main Article

1Current affiliation: Guardant Health, Redwood City, California, USA.

Page created: July 07, 2022
Page updated: August 19, 2022
Page reviewed: August 19, 2022
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