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Volume 29, Number 1—January 2023
Dispatch

Genomic Microevolution of Vibrio cholerae O1, Lake Tanganyika Basin, Africa

Yaovi M.G. Hounmanou, Elisabeth Njamkepo, Jean Rauzier, Karin Gallandat, Aurélie Jeandron, Guyguy Kamwiziku, Klaudia Porten, Francisco Luquero, Aaron Aruna Abedi, Baron Bashige Rumedeka, Berthe Miwanda, Martin Michael, Placide Welo Okitayemba, Jaime Mufitini Saidi, Renaud Piarroux, François-Xavier Weill, Anders Dalsgaard, and Marie-Laure QuiliciComments to Author 
Author affiliations: University of Copenhagen, Frederiksberg, Denmark (Y.M.G. Hounmanou, A. Dalsgaard); Institut Pasteur, Université Paris Cité, Paris, France (E. Njamkepo, J. Rauzier, F.-X. Weill, M.-L. Quilici); London School of Hygiene and Tropical Medicine, London, UK (K. Gallandat, A. Jeandron); University of Kinshasa, Kinshasa, Democratic Republic of the Congo (G. Kamwiziku); Epicentre, Paris (K. Porten, F. Luquero); Ministry of Public Health, Kinshasa (A. Aruna Abedi, P. Welo Okitayemba); Ministry of Public Health, Uvira, Democratic Republic of the Congo (B. Bashige Rumedeka, J. Mufitini Saidi); Institut National de Recherche Biomédicale, Kinshasa (B. Miwanda); Sokoine University of Agriculture College of Veterinary Medicine and Biomedical Sciences, Morogoro, Tanzania (M. Michael); Sorbonne Université, Inserm UMR 1136, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris (R. Piarroux)

Main Article

Figure 1

Phylogenomics of clinical and environmental Vibrio cholerae O1 El Tor isolates from the Lake Tanganyika basin, Africa. A) Maximum-likelihood phylogeny of 1,366 seventh pandemic V. cholerae O1 El Tor (7PET) genomes with strain A6 as the outgroup. The different sublineages introduced into Africa are indicated. Light blue indicates AFR10 sublineage. Rings 1 and 2 show geographic origin of isolates; ring 3 shows isolates sequenced in this study. B) Maximum-likelihood tree for 357 AFR10 isolates, with strain N16961 as an outgroup. The 5 clades are color-coded: AFR10a, brown; AFR10b, yellow; AFR10c, green; AFR10d, pink; and AFR10e, blue. The outermost ring indicates the geographic locations of the different isolates in the tree. Filled circles indicate the presence of ST69 or ST515, Ogawa and Inaba serotypes, IncA/C plasmid, and the S85L mutation in parC; open circles indicate their absence. MLST, multilocus sequence typing; ST, sequence type.

Figure 1. Phylogenomics of clinical and environmental Vibrio cholerae O1 El Tor isolates from the Lake Tanganyika basin, Africa. A) Maximum-likelihood phylogeny of 1,366 seventh pandemic V. cholerae O1 El Tor (7PET) genomes with strain A6 as the outgroup. The different sublineages introduced into Africa are indicated. Light blue indicates AFR10 sublineage. Rings 1 and 2 show geographic origin of isolates; ring 3 shows isolates sequenced in this study. B) Maximum-likelihood tree for 357 AFR10 isolates, with strain N16961 as an outgroup. The 5 clades are color-coded: AFR10a, brown; AFR10b, yellow; AFR10c, green; AFR10d, pink; and AFR10e, blue. The outermost ring indicates the geographic locations of the different isolates in the tree. Filled circles indicate the presence of ST69 or ST515, Ogawa and Inaba serotypes, IncA/C plasmid, and the S85L mutation in parC; open circles indicate their absence. MLST, multilocus sequence typing; ST, sequence type.

Main Article

Page created: December 09, 2022
Page updated: December 22, 2022
Page reviewed: December 22, 2022
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