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Volume 29, Number 1—January 2023
Dispatch

Genomic Microevolution of Vibrio cholerae O1, Lake Tanganyika Basin, Africa

Yaovi M.G. Hounmanou, Elisabeth Njamkepo, Jean Rauzier, Karin Gallandat, Aurélie Jeandron, Guyguy Kamwiziku, Klaudia Porten, Francisco Luquero, Aaron Aruna Abedi, Baron Bashige Rumedeka, Berthe Miwanda, Martin Michael, Placide Welo Okitayemba, Jaime Mufitini Saidi, Renaud Piarroux, François-Xavier Weill, Anders Dalsgaard, and Marie-Laure QuiliciComments to Author 
Author affiliations: University of Copenhagen, Frederiksberg, Denmark (Y.M.G. Hounmanou, A. Dalsgaard); Institut Pasteur, Université Paris Cité, Paris, France (E. Njamkepo, J. Rauzier, F.-X. Weill, M.-L. Quilici); London School of Hygiene and Tropical Medicine, London, UK (K. Gallandat, A. Jeandron); University of Kinshasa, Kinshasa, Democratic Republic of the Congo (G. Kamwiziku); Epicentre, Paris (K. Porten, F. Luquero); Ministry of Public Health, Kinshasa (A. Aruna Abedi, P. Welo Okitayemba); Ministry of Public Health, Uvira, Democratic Republic of the Congo (B. Bashige Rumedeka, J. Mufitini Saidi); Institut National de Recherche Biomédicale, Kinshasa (B. Miwanda); Sokoine University of Agriculture College of Veterinary Medicine and Biomedical Sciences, Morogoro, Tanzania (M. Michael); Sorbonne Université, Inserm UMR 1136, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris (R. Piarroux)

Main Article

Table

Characteristics of Vibrio cholerae O1 isolates from humans and the environment around Lake Tanganyika, Africa, 2015–2020*

Characteristic 2015 2016 2017 2018 2019 2020
No. isolates
 26
 7
 14
 14
 7
 28
AFR10 clade AFR10d (1) AFR10d (5) AFR10e AFR10e AFR10e AFR10e
AFR10e (25)
 AFR10e (2)
Serotype Inaba (1) Inaba (5) Ogawa Ogawa Ogawa Ogawa
Ogawa (25)
 Ogawa (2)
Source Human Human Human Human (10) Human (1) Human
Fish (2) Fish (4)
Water (2)
 Water (2)
MLST ST515 (1) ST515 (5) ST69 ST69 ST69 ST69
ST69 (25)
 ST69 (2)
Antimicrobial resistance determinants
SXT/R391 element ICEVchInd5 ICEVchInd5 ICEVchInd5† ICEVchInd5 ICEVchInd5 ICEVchInd5
gyrA S83I S83I S83I S83I S83I S83I
parC S85L S85L (2), WT (5) S85L S85L S85L S85L
VC_0715 R169C R169C R169C R169C R169C R169C
VC_A0637 Q5Stop Q5Stop Q5Stop Q5Stop Q5Stop Q5Stop
AMR AMR1‡ (26) AMR1‡ (2) AMR1‡ (13) AMR1 (14)‡ AMR1 (7)‡ AMR1 (28)‡
AMR2§ (5) AMR3¶ (1)

*Numbers in parentheses indicate number of isolates for each designation. AMR, antimicrobial resistance patterns; CIP, ciprofloxacin; DS, decreased susceptibility; FUR, nitrofurantoin; MLST, multilocus sequence typing; NAL, nalidixic acid; O129, cross-resistance to the vibriostatic agent O/129 and trimethoprim; PMB, polymyxin B; SSS, sulfonamides; ST, sequence type; STR, streptomycin; SXT, trimethoprim/sulfamethoxazole †Deletion of the strA, strB, floR, and sul2 genes in isolate CNRVC170308 (all isolates with intact ICEVchInd5 harbor the strA, strB, dfrA1, floR, and sul2 resistance genes) ‡Resistance to STR, SSS, O129, SXT, FUR, PMB, NAL, and CIPDS. §Resistance to STR, SSS, O129, SXT, FUR, PMB, and NAL.
¶Resistance to O129, FUR, PMB, NAL, CIPDS.

Main Article

Page created: December 09, 2022
Page updated: December 22, 2022
Page reviewed: December 22, 2022
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