Volume 29, Number 1—January 2023
Research
Human Immunity and Susceptibility to Influenza A(H3) Viruses of Avian, Equine, and Swine Origin
Elien Vandoorn, Wojciech Stadejek, Isabel Leroux-Roels, Geert Leroux-Roels, Anna Parys, and Kristien Van Reeth
Table 5
Geometric mean of virus neutralization antibody titers against H3 influenza A viruses of different species in different age groups of the human population, 2017–2018, Belgium*
| Birth year range (age, y)† |
No. | Avian |
Equine |
Human |
Swine |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dkUK63 |
mlOH18 |
mlBE18 |
chG19 |
eqCH18 |
HK68‡ |
swG17 |
swIN16 |
swMO15 |
|||||
| Eurasian | Am. | Eurasian | Eurasian | FC1 | Pandemic | European | N. Am. | N. Am. | |||||
| 1921–1926 (96–91) | 14 | 7 (5–9) | 10 (7–15) | 8 (6–12) | 6 (5–7) | 7 (5–10) | 30 (12–72) | 10 (5–19) | 104 (44–247) | 116 (38–351) | |||
| 1927–1936 (90–81) | 30 | 6 (5–7) | 12 (9–18) | 12 (8–17) | 6 (5–7) | 7 (5–8) | 43 (27–68) | 9 (6–11) | 60 (34–106) | 105 (62–176) | |||
| 1937–1946 (80–71) | 30 | 5 (5–6) | 9 (7–12) | 10 (7–14) | 5 (5–6) | 6 (5–6) | 48 (32–72) | 9 (6–12) | 33 (21–53) | 79 (46–137) | |||
| 1947–1956 (70–61) | 30 | 7 (5–9) | 14 (10–21) | 15 (11–22) | 6 (5–7) | 7 (5–9) | 69 (44–110) | 8 (6–11) | 31 (18–52) | 35 (20–60) | |||
| 1957–1966 (60–51) | 30 | 6 (5–7) | 15 (11–20) | 19 (13–27) | 7 (5–9) | 6 (5–6) | 100 (72–138) | 12 (8–16) | 28 (17–47) | 37 (24–56) | |||
| 1967–1976 (50–41) | 30 | 7 (5–9) | 11 (8–17) | 12 (8–17) | 6 (5–7) | 6 (5–7) | 31 (17–55) | 18 (13–25) | 94 (56–157) | 60 (35–103) | |||
| 1977–1986 (40–31) | 30 | 6 (5–7) | 7 (6–8) | 6 (5–7) | 5 (5–6) | 8 (6–10) | 9 (6–13) | 9 (7–12) | 285 (175–462) | 84 (45–154) | |||
| 1987–1996 (30–21) | 30 | 5 (5–5) | 6 (5–6) | 5 (5–6) | 5 (5–5) | 6 (5–7) | 6 (5–6) | 7 (6–8) | 219 (129–372) | 225 (156–323) | |||
| 1997–2006 (20–11) | 30 | 5 (5–5) | 5 (5–5) | 5 (5–5) | 5 (5–5) | 5 (5–6) | 5 (5–6) | 6 (5–7) | 18 (11–29) | 163 (96–275) | |||
| 2007–2017 (10–0) |
32 |
5 (5–5) |
5 (5–5) |
5 (5–5) |
5 (5–5) |
6 (5–7) |
6 (5–7) |
6 (5–6) |
8 (6–10) |
40 (24–67) |
|||
| 1921–2017 (96–0) | 286 | 6 (5–6) | 9 (8–10) | 9 (8–10) | 6 (5–6) | 6 (6–7) | 21 (18–25) | 9 (8–9) | 49 (40–60) | 77 (64–91) | |||
*Values represent geometric mean virus neutralization titers (95% CI). Viruses are ordered according to host species and chronologically according to the emergence of each of the influenza A virus lineages in these species. Complete isolate names are provided in [[ANCHOR###T2###Table 2###Anchor]]. Am., American; FC1, Florida clade 1; N. Am., North American. †Age at the end of 2017. ‡Human influenza A virus that no longer circulates.
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