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Volume 29, Number 10—October 2023
CME ACTIVITY - Synopsis

Serotype Distribution and Disease Severity in Adults Hospitalized with Streptococcus pneumoniae Infection, Bristol and Bath, UK, 2006‒2022

Catherine Hyams1Comments to Author , Robert Challen1, David Hettle, Zahin Amin-Chowdhury, Charli Grimes, Gabriella Ruffino, Rauri Conway, Robyn Heath, Paul North, Adam Malin, Nick A. Maskell, Philip Williams, O. Martin Williams, Shamez N. Ladhani, Leon Danon, and Adam Finn
Author affiliations: University of Bristol, Bristol, UK (C. Hyams, R. Challen, R. Heath, L. Danon, A. Finn); Southmead Hospital, Bristol (C. Hyams, C. Grimes, G. Ruffino, R. Conway, N.A. Maskell, A. Finn); Bristol Royal Infirmary, Bristol (D. Hettle, P. North, P. Williams, O.M. Williams); UK Health Security Agency, London, UK (Z. Amin-Chowdhury, S.N. Ladhani); The Royal United Hospital, Bath, UK (A. Malin)

Main Article

Figure 3

Severity of manifestations and outcome of invasive pneumococcal disease in hospitalized adults over time, Bristol, UK. A) Age categories; B) CURB65 scores; C) ICU admissions; D) inpatient deaths; E) length of stay in a hospital. For panels A, B, and E, categories are shown in the legend adjacent to each panel. The solid line in the multinomial time series models shown in panels C and D indicates binomial time series models; gray areas indicate 95% CIs. Across all panels, vertical lines indicate dates of 7-valent PCV (PCV7) (solid black) and PCV13 2 + 1 (thin black dashed line) and 1 + 1 (thick dash blacked line) schedule vaccine introduction and SARS-CoV-2 emergence (solid gray). Results for noninvasive pneumococcal disease are shown in the Appendix. ICU, intensive care unit; PCV, pneumococcal conjugate vaccine.

Figure 3. Severity of manifestations and outcome of invasive pneumococcal disease in hospitalized adults over time, Bristol, UK. A) Age categories; B) CURB65 scores; C) ICU admissions; D) inpatient deaths; E) length of stay in a hospital. For panels A, B, and E, categories are shown in the legend adjacent to each panel. The solid line in the multinomial time series models shown in panels C and D indicates binomial time series models; gray areas indicate 95% CIs. Across all panels, vertical lines indicate dates of 7-valent PCV (PCV7) (solid black) and PCV13 2 + 1 (thin black dashed line) and 1 + 1 (thick dash blacked line) schedule vaccine introduction and SARS-CoV-2 emergence (solid gray). Results for noninvasive pneumococcal disease are shown in the Appendix. ICU, intensive care unit; PCV, pneumococcal conjugate vaccine.

Main Article

1These authors contributed equally to this article.

Page created: July 31, 2023
Page updated: September 15, 2023
Page reviewed: September 15, 2023
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