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Volume 29, Number 10—October 2023
CME ACTIVITY - Synopsis

Serotype Distribution and Disease Severity in Adults Hospitalized with Streptococcus pneumoniae Infection, Bristol and Bath, UK, 2006‒2022

Catherine Hyams1Comments to Author , Robert Challen1, David Hettle, Zahin Amin-Chowdhury, Charli Grimes, Gabriella Ruffino, Rauri Conway, Robyn Heath, Paul North, Adam Malin, Nick A. Maskell, Philip Williams, O. Martin Williams, Shamez N. Ladhani, Leon Danon, and Adam Finn
Author affiliations: University of Bristol, Bristol, UK (C. Hyams, R. Challen, R. Heath, L. Danon, A. Finn); Southmead Hospital, Bristol (C. Hyams, C. Grimes, G. Ruffino, R. Conway, N.A. Maskell, A. Finn); Bristol Royal Infirmary, Bristol (D. Hettle, P. North, P. Williams, O.M. Williams); UK Health Security Agency, London, UK (Z. Amin-Chowdhury, S.N. Ladhani); The Royal United Hospital, Bath, UK (A. Malin)

Main Article

Table 1

Characteristics of patients hospitalized with confirmed pneumococcal infection, Bristol, UK, 2006–2022*

Characteristic Invasive disease, n = 1,686 Noninvasive disease, n = 2,033 p value
Age, y, median (IQR)
 65.9 (50.8‒79)
 66.3 (50‒78.8)
 0.74
Sex
M 847 (50.2) 993 (48.8) 0.41
F
 839 (49.8)
1,040 (51.2)
Serotype status
Serotype identified 1,501 (89.0) 0 <0.001
No serotype
 185 (11.0)
 2,033 (100.0)
Smoker
Nonsmoker 495 (29.4) 597 (29.4) 0.95
Ex-smoker 680 (40.3) 829 (40.8)
Current smoker
 511 (30.3)
 607 (29.9)
Charlson Comorbidity Index, median (IQR)
 4 (1‒6)
 4 (1‒6)
 0.31
Test type
Blood culture only 1,325 (78.6) 0 (0) <0.001
UAT only 51 (3.0) 2,033 (100.0)
Blood culture and UAT 295 (17.5) 0
CSF PCR 8 (0.5) 0
Blood PCR
 7 (0.4)
 0
Infection site
Lung 1,419 (84.2) 2,017 (99.2) <0.001
Meningitis 172 (10.2) 0
Septic arthritis 36 (2.1) 0
ENT 15 (0.9) 2 (0.1)
Other
 44 (2.6)
 14 (0.7)
PPV23 vaccination, time before illness
None 967 (57.4) 1,171 (57.6) 0.99
<6 mo 60 (3.6) 72 (3.5)
>6 mo 659 (39.1) 789 (38.8)
Missing
 0
 1 (0)
Noninvasive ventilation 39 (2.3) 103 (5.1) <0.001
Intubation 236 (14.0) 234 (11.5) 0.026
Inpatient death† 255 (15.1) 253 (12.4) 0.019

*Values are no. (%) except as indicated. Significance was determined by using the Fisher exact test for categorical variables, the 2-sample Kolmogorov-Smirnov test (continuous variables), and the 2-sample Wilcoxon rank-sum test (continuous variables). Normality of distributions determined by using the Anderson-Darling normality test. CSF, cerebrospinal fluid; ENT, ear, nose, and throat; IQR, interquartile range; PPV23, 23-valent pneumococcal polysaccharide vaccine; UAT, urine antigen test. †Determined though review of medical records (i.e., death before discharge from hospital).

Main Article

1These authors contributed equally to this article.

Page created: July 31, 2023
Page updated: September 15, 2023
Page reviewed: September 15, 2023
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