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Volume 29, Number 10—October 2023
Research

Ancestral Origin and Dissemination Dynamics of Reemerging Toxigenic Vibrio cholerae, Haiti

Carla N. Mavian, Massimiliano S. Tagliamonte, Meer T. Alam, S. Nazmus Sakib, Melanie N. Cash, Monika Moir, Juan Perez Jimenez, Alberto Riva, Eric J. Nelson, Emilie T. Cato, Jayakrishnan Ajayakumar, Rigan Louis, Andrew Curtis, V. Madsen Beau De Rochars, Vanessa Rouzier, Jean William Pape, Tulio de Oliveira, J. Glenn Morris1Comments to Author , Marco Salemi1, and Afsar Ali1
Author affiliations: University of Florida, Gainesville, Florida, USA (C.N. Mavian, M.S. Tagliamonte, M.T. Alam, S.N. Sakib, M.N. Cash, J.P. Jimenez, A. Riva, E.J. Nelson, E.T. Cato, R. Louis, V.M. Beau De Rochars, J.G. Morris Jr., M. Salemi, A. Ali); Stellenbosch University, Stellenbosch, South Africa (M. Moir, T. de Oliveira); Case Western Reserve University School of Medicine, Cleveland, Ohio, USA (J. Ajayakumar, A. Curtis); Les Centres GHESKIO, Port-au-Prince, Haiti (V. Rouzier, J.W. Pape); Weill Cornell Medical College, New York, New York, USA (V. Rouzier, J.W. Pape); University of KwaZulu-Natal, Durban, South Africa (T. de Oliveira); Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa (T. de Oliveira); University of Washington, Seattle, Washington, USA (T. de Oliveira)

Main Article

Table

Bayesian hypothesis testing of monophyly used in a study of ancestral origin and dissemination dynamic of reemerging toxigenic Vibrio cholerae, Haiti*

Monophyly testing† lml(ML)SS‡ Ln(BF)SS§ lml(ML)PS‡ Ln(BF)PS§
Monophyly enforced with Ogawa 2014–2018 clade –1,985.9 95.3 –1,988.4 94.5

*BF, Bayes factor; lml, log marginal likelihood; Ln, log; MCC, maximum clade credibility; ML, maximum-likelihood; SS, stepping-stone; PS, path sampling. †The test compares the MCC tree topology in Figure 5, panel B (H0), between 2022 environmental strains and 2018 environmental strain ENV515. Alternative topologies were obtained by enforcing monophyly with other strains (HA). ‡log of marginal likelihood estimates, lml(MLE), obtained by SS or PS by using a strict molecular clock and a Bayesian skyline demographic prior, with or without enforcing monophyly between the 2022 Haiti strains and different clinical strains. §log of BF comparing the null (H0) and alternative (HA) hypotheses.

Main Article

1These senior authors contributed equally to this article.

Page created: August 05, 2023
Page updated: September 20, 2023
Page reviewed: September 20, 2023
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