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Volume 29, Number 11—November 2023
Research Letter

Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae

Qiaozhen Cui1, Chen Wang1, Qichen Wang, Juanxiu Qin, Min Li, Baixing DingComments to Author , and Zhen ShenComments to Author 
Author affiliations: Shanxi Provincial People's Hospital, Taiyuan, China (Q. Cui); Renji Hospital at Shanghai Jiao Tong University School of Medicine, Shanghai, China (C. Wang, Q. Wang, J. Qin, M. Li, Z. Shen); Huashan Hospital at Fudan University, Shanghai (B. Ding); Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai (B. Ding)

Main Article

Figure 2

Overexpression of blaSHV-12 contributing to ceftazidime/avibactam resistance in Klebsiella. pneumoniae isolate KP0714 in study of ceftazidime/avibactam resistance in carbapenemase-producing K. pneumoniae. A) Relative blaSHV-12 expression level. B) Ceftazidime hydrolysis activity of different blaSHV-12 promoter deletion mutants. One unit of enzyme activity was defined as the amount of enzyme that hydrolyzed 1 nmol of substrate per min. Error bars indicate SDs. p values were computed by 1-way analysis of variance with Bonferroni correction.

Figure 2. Overexpression of blaSHV-12 contributing to ceftazidime/avibactam resistance in Klebsiella. pneumoniae isolate KP0714 in study of ceftazidime/avibactam resistance in carbapenemase-producing K. pneumoniae. A) Relative blaSHV-12 expression level. B) Ceftazidime hydrolysis activity of different blaSHV-12 promoter deletion mutants. One unit of enzyme activity was defined as the amount of enzyme that hydrolyzed 1 nmol of substrate per min. Error bars indicate SDs. p values were computed by 1-way analysis of variance with Bonferroni correction.

Main Article

1These first authors contributed equally to this article.

Page created: September 28, 2023
Page updated: October 23, 2023
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