Volume 29, Number 11—November 2023
Research Letter
Genomic Sequencing Surveillance to Identify Respiratory Syncytial Virus Mutations, Arizona, USA
LaRinda A. Holland1, Steven C. Holland1, Matthew F. Smith, Victoria R. Leonard, Vel Murugan, Lora Nordstrom, Mary Mulrow, Raquel Salgado, Michael White, and Efrem S. Lim
Table
Nonsynonymous amino acid substitutions in RSV-A and RSV-B F protein antigenic sites found in genome sequences in Arizona, USA, during 2022–2023 compared with GISAID global genome sequences
| Mutation | Antigenic site | Global frequency, no. (%) |
Arizona frequency,† no. (%) | |||
|---|---|---|---|---|---|---|
| 2020 | 2021 | 2022 | 2023† | |||
| RSV-A | n = 967 | n = 1,144 | n = 740 | n = 115 | n = 92 | |
| I57V | V | 0 | 0 | 19 (3) | 1 (1) | 2 (2) |
| I59V | V | 2 (<1) | 1 (<1) | 0 | 0 | 1 (1) |
| S276N | II | 29 (3) | 51 (4) | 142 (19) | 14 (12) | 4 (4) |
| V379A | I | 0 | 0 | 1 (<1) | 0 | 8 (9) |
| L381I | I | 0 | 0 | 0 | 0 | 1 (1) |
| P389S | I | 0 | 5 (<1) | 3 (<1) | 0 | 2 (2) |
| K470R |
IV |
0 |
0 |
0 |
0 |
1 (1) |
| RSV-B | n = 305 | n = 812 | n = 720 | n = 126 | n = 24 | |
| R42K | I | 1 (<1) | 15 (2) | 61 (8) | 16 (13) | 18 (75) |
| S190N | V | 9 (3) | 191 (24) | 400 (56) | 116 (92) | 24 (100) |
| S211N | Ø | 1 (<1) | 195 (24) | 399 (55) | 116 (92) | 24 (100) |
| E378D | III | 1 (<1) | 0 | 0 | 0 | 2 (8) |
| S389P |
I |
0 |
193 (24) |
412 (57) |
116 (92) |
24 (100) |
| *GISAID, https://www.gisaid.org; RSV, respiratory syncytial virus. †Through April 30, 2023. |
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1These first authors contributed equally to this article.
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Page updated: October 23, 2023
Page reviewed: October 23, 2023
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