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Volume 29, Number 12—December 2023
Research

Fatal Human Neurologic Infection Caused by Pigeon Avian Paramyxovirus-1, Australia

Siobhan Hurley1Comments to Author , John Sebastian Eden1, John Bingham, Michael Rodriguez, Matthew J. Neave, Alexandra Johnson, Annaleise R. Howard-Jones, Jen Kok, Antoinette Anazodo, Brendan McMullan, David T. Williams, James Watson, Annalisa Solinas, Ki Wook Kim2, and William Rawlinson2
Author affiliations: Prince of Wales Hospital, Randwick, New South Wales, Australia (S. Hurley, K.W. Kim); Westmead Institute for Medical Research Centre for Virus Research, Westmead, New South Wales, Australia (J.S. Eden); Sydney Institute for Infectious Diseases, University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia (J.S. Eden, A.R. Howard-Jones); CSIRO Australian Centre for Disease Preparedness, Geelong, Victoria, Australia (J. Bingham, M.J. Neave, D.T. Williams, J. Watson); Prince of Wales and Sydney Children’s Hospital, Randwick (M. Rodriguez, A. Solinas); Sydney Children’s Hospital, Randwick (A. Johnson, B. McMullan); Centre for Infectious Diseases and Microbiology Laboratory Services, New South Wales Health Pathology–Institute of Clinical Pathology and Medical Research, Westmead (A.R. Howard-Jones, J. Kok); Kids Cancer Centre, Sydney Children’s Hospital, Randwick (A. Anazodo); University of New South Wales Faculty of Medicine and Health, School of Clinical Medicine, Sydney (B. McMullan, K. Kim); Prince of Wales Hospital and Community Health Services, Sydney (W. Rawlinson); University of New South Wales Schools of Clinical Medicine, Biotechnology and Biomolecular Sciences, Sydney (W. Rawlinson)

Main Article

Figure 3

Genomic markers of virulence in avian paramyxovirus type 1 strain in an immunocompromised child in Australia. An analysis of both P and F genes indicated the strain would likely be classified as virulent based on P-gene editing; possible alternate reading frames were detected in mapped sequence reads (left side of panel). The F gene protein sequence carries a polybasic cleavage site at amino acid positions 112–116 (region on right of panel). CDS, coding sequences; F, fusion protein; G, glycoprotein; HN, hemagglutinin-neuraminidase protein; L, large protein; M, matrix protein; NP, nucleoprotein; P, polymerase-associated phosphoprotein.

Figure 3. Genomic markers of virulence in avian paramyxovirus type 1 strain in an immunocompromised child in Australia. An analysis of both P and F genes indicated the strain would likely be classified as virulent based on P-gene editing; possible alternate reading frames were detected in mapped sequence reads (left side of panel). The F gene protein sequence carries a polybasic cleavage site at amino acid positions 112–116 (region on right of panel). CDS, coding sequences; F, fusion protein; G, glycoprotein; HN, hemagglutinin-neuraminidase protein; L, large protein; M, matrix protein; NP, nucleoprotein; P, polymerase-associated phosphoprotein.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: November 13, 2023
Page updated: November 18, 2023
Page reviewed: November 18, 2023
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