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Volume 29, Number 2—February 2023
Research

Penicillin and Cefotaxime Resistance of Quinolone-Resistant Neisseria meningitidis Clonal Complex 4821, Shanghai, China, 1965–2020

Mingliang Chen1, Youxing Shao1, Jiayuan Luo, Lingyue Yuan, Minggui WangComments to Author , Min ChenComments to Author , and Qinglan GuoComments to Author 
Author affiliations: Shanghai Institutes of Preventive Medicine, Shanghai, China (Mingliang Chen); Shanghai Municipal Center for Disease Control and Prevention, Shanghai (Mingliang Chen, J. Luo, L. Yuan, Min Chen); Huashan Hospital, Fudan University, Shanghai (Y. Shao, M. Wang, Q. Guo); Key Laboratory of Clinical Pharmacology of Antibiotics, National Heath Commission of the People's Republic of China, Shanghai (Y.Shao, M.G. Wang, Q. Guo)

Main Article

Table

Frequency of identification of penicillin-nonsusceptible meningococcal isolates, Shanghai, China, 1965–2020*

Isolate source
Total
1965–1985
2005–2020
Total
2005–2014
2015–2020
Total
26/491 (5.3)
1/303 (0.3)
25/188 (13.3)
10/143 (7.0)
15/45 (33.3)
IMD, n = 171
Average 6/17 (3.5) 0/124 (0) 6/47 (12.8) 1/38 (2.6) 5/9 (55.6)
Age <18 y 4/81 (4.9) 0/46 (0) 4/35 (11.4) 1/29 (3.4) 3/6 (50)
Age >18 y
2/90 (2.2)
0/78 (0)
2/12 (16.7)
0/9 (0)
2/3 (66.7)
Carriage, n = 320
Average 20/320 (6.3) 1/179 (0.6) 19/141 (13.5) 9/105 (8.6) 10/36 (27.8)
Age <18 y 12/51 (23.5) 0/8 (0) 12/43 (27.9) 3/22 (13.6) 9/21 (42.9)
Age >18 y 8/269 (3.0) 1/171 (0.6) 7/98 (7.1) 6/83 (7.2) 1/15 (6.7)

*Values are no./no. nonsusceptible isolates (%). IMD, invasive meningococcal disease.

Main Article

1These authors contributed equally to this article.

Page created: December 20, 2022
Page updated: January 21, 2023
Page reviewed: January 21, 2023
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