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Volume 29, Number 4—April 2023
Dispatch

Emergence and Persistent Dominance of SARS-CoV-2 Omicron BA.2.3.7 Variant, Taiwan

Pei-Lan Shao1, Hsiao-Chen Tu1, Yu-Nong Gong1, Hung-Yu Shu, Ralph Kirby, Li-Yun Hsu, Hui-Yee Yeo, Han-Yueh Kuo, Yi-Chia Huang, Yung-Feng Lin, Hui-Ying Weng, Yueh-Lin Wu, Chien-Chih Chen, Tzen-Wen Chen, Kuo-Ming Lee, Chung-Guei Huang, Shin-Ru Shih, Wei J. Chen, Chen-Chi Wu, Chong-Jen YuComments to Author , and Shih-Feng TsaiComments to Author 
Author affiliations: National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan (P.-L. Shao, L.-Y. Hsu, H.-Y. Yeo, H.-Y. Kuo, Y.-C. Huang, C.-C. Wu, C.-J. Yu); Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan (H.-C. Tu, Y.-F. Lin, S.-F. Tsai); Research Center for Emerging Viral Infections, Chang Gung University College of Medicine, Taoyuan, Taiwan (Y.-N. Gong, K.-M. Lee, C.-G. Huang, S.-R. Shih); Linkou Chang Gung Memorial Hospital, Taoyuan (Y.-N. Gong, K.-M. Lee, C.-G. Huang S.-R. Shih); Chang Gung University College of Medicine, Taoyuan (Y.-N. Gong, K.-M. Lee, C.-G. Huang, S.-R. Shih); Chang Jung Christian University, Tainan, Taiwan (H.-Y. Shu); National Yang Ming Chiao Tung University, Taipei, Taiwan (R. Kirby, H.-Y. Weng, S.-F. Tsai); National Yang-Ming University, Taipei (H.-Y. Weng); TMU Research Center of Urology and Kidney, Taipei Medical University, Taipei, Taiwan (Y.-L. Wu); Wei-Gong Memorial Hospital, Miaoli, Taiwan (Y.-L. Wu, C.-C. Chen, T.-W. Chen,); Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli (W.-J. Chen); Institute of Epidemiology and Preventive Medicine, National Taiwan University College of Public Health, Taipei (W.-J. Chen); National Taiwan University College of Medicine, Taipei (C.-C. Wu)

Main Article

Table 1

Signature mutations in SARS-CoV-2 BA.2.3.7 sublineages of viral samples from a study of the Omicron BA.2.3.7 variant in community outbreaks, Taiwan

Lineage
 Accumulated mutations*
 Selected mutations†
BA.2
 BA.2.3
 BA.2.3.7
ORF1a S135R S135R S135R NA
NA NA NA A591V
NA NA L631F L631F
T842I T842I T842I NA
NA NA NA I1091T
G1307S G1307S G1307S NA
NA A2909V A2909V NA
L3027F L3027F L3027F NA
T3090I T3090I T3090I NA
L3201F L3201F L3201F NA
NA NA NA T3224A
T3255I T3255I T3255I NA
P3395H P3395H P3395H NA
del3675 del3675 del3675 NA
del3676 del3676 del3676 NA
del3677 del3677 del3677 NA
NA
 NA
 NA
 V3683I
Spike T19I T19I T19I NA
L24S L24S L24S NA
del25 del25 del25 NA
del26 del26 del26 NA
del27 del27 del27 NA
NA NA K97E K97E
G142D G142D G142D NA
V213G V213G V213G NA
G339D G339D G339D NA
S371F S371F S371F NA
S373P S373P S373P NA
S375F S375F S375F NA
T376A T376A T376A NA
D405N D405N D405N NA
R408S R408S R408S NA
K417N K417N K417N NA
N440K N440K N440K NA
S477N S477N S477N NA
T478K T478K T478K NA
E484A E484A E484A NA
Q493R Q493R Q493R NA
Q498R Q498R Q498R NA
N501Y N501Y N501Y NA
Y505H Y505H Y505H NA
D614G D614G D614G NA
H655Y H655Y H655Y NA
N679K N679K N679K NA
P681H P681H P681H NA
N764K N764K N764K NA
D796Y D796Y D796Y NA
Q954H Q954H Q954H NA
N969K N969K N969K NA
NA
 NA
 NA
 G1251V
ORF3a NA L140F L140F NA
T223I
 T223I
 T223I
 NA
Nucleocapsid P13L P13L P13L NA
del31 del31 del31 NA
del32 del32 del32 NA
del33 del33 del33 NA
R203K R203K R203K NA
G204R G204R G204R NA
NA NA M322I M322I
S413R S413R S413R NA

*Using SARS-CoV-2 Wuhan-Hu-1 (GenBank accession no. MN908947.3) as the reference sequence. Mutations in ORF1b, E, M, ORF6, and ORF8 are not shown as they are identical between BA.2, BA.2.3 and BA.2.3.7. NA, not applicable; ORF, open reading frame. †Mutations detected in the Omicron lineages are characterized in this study.

Main Article

1These authors contributed equally to this article.

Page created: January 24, 2023
Page updated: March 21, 2023
Page reviewed: March 21, 2023
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