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Volume 29, Number 4—April 2023

Research

Monitoring Temporal Changes in SARS-CoV-2 Spike Antibody Levels and Variant-Specific Risk for Infection, Dominican Republic, March 2021–August 2022

Eric J. NillesComments to Author , Michael de St. Aubin, Devan Dumas, William Duke, Marie Caroline Etienne, Gabriela Abdalla, Petr Jarolim, Timothy Oasan, Salome Garnier, Naomi Iihoshi, Beatriz Lopez, Lucia de la Cruz, Yosanly Cornelio Puello, Margaret Baldwin, Kathryn W. Roberts, Farah Peña, Kara Durski, Isaac Miguel Sanchez, Sarah M. Gunter, Alexander R. Kneubehl, Kristy O. Murray, Allison Lino, Sarah Strobel, Amado Alejandro Baez, Colleen L. Lau, Adam Kucharski, Emily Zielinski Gutiérrez, Ronald Skewes-Ramm, Marietta Vasquez1, and Cecilia Then Paulino1
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (E.J. Nilles, M. de St. Aubin, D. Dumas, M.C. Etienne, G. Abdalla, P. Jarolim, T. Oasan, S. Garnier, N. Iihoshi, M. Baldwin, K.W. Roberts, K. Durski); Harvard Humanitarian Initiative, Cambridge, Massachusetts, USA (E.J. Nilles, M. de St. Aubin, D. Dumas, S. Garnier, M. Baldwin, K.W. Roberts, K. Durski); Harvard Medical School, Boston (E.J. Nilles, P. Jarolim); Pedro Henríquez Ureña National University, Santo Domingo, Dominican Republic (W. Duke); US Centers for Disease Control and Prevention, Central America Regional Office, Guatemala City, Guatemala (B. Lopez, E. Zielinski Gutiérrez); Ministry of Health and Social Assistance, Santo Domingo (L. de la Cruz, Y. Cornelio Puello, F. Peña, I.M. Sanchez, R. Skewes-Ramm, C. Then Paulino); Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas, USA (S.M. Gunter, A.R. Kneubehl, K.O. Murray, A. Lino, S. Strobel); Dominican Republic Office of the Presidency, Santo Domingo (A.A. Baez); University of Queensland, Brisbane, Queensland, Australia (C.L. Lau); London School of Hygiene and Tropical Medicine, London, England, UK (A. Kucharski); Yale School of Medicine, New Haven, Connecticut, USA (M. Vasquez)

Main Article

Table 2

SARS-CoV-2 spike binding antibody serostatus, geometric mean titers, and median titers of participants in study of SARS-CoV-2 spike antibody levels, by study period interval, Dominican Republic, March 2021–August 2022*

Study period interval No. patients Seropositive, no. (%)† GMT (95% CI) Median titer, BAU/mL (Q1—Q3)
Mar–Jun 2021 434 265 (61.1) 6.6 (5.1–8.7) 3.8 (0.4–57.5)
Jul–Sep 2021 397 344 (86.6) 62.8 (45.8–86.0) 62.5 (6.0–581.8)
Oct–Dec 2021 579 543 (93.8) 559.4 (439.8–711.5) 781.7 (104.9–4,813.5)
Jan–Apr 2022 463 434 (93.7) 1,180.3 (906.3–1,537.2) 2,578 (390.8–8,137.5)
May–Aug 2022 427 409 (95.8) 1,332.4 (1,055.3–1,682.3) 2,876 (775.8–5,483.5)

*N = 2,300. Study periods indicate complete months except March 2021, which represents enrollment starting March 22, 2021, and August 2022, which represents enrollment through August 17, 2022. BAU, binding antibody units; GMT, geometric mean titer. †Seropositive defined as SARS-CoV-2 spike binding antibodies above the test manufacturer’s cutoff index (>0.8 BAU/mL).

Main Article

1These authors contributed equally to this article.

Page created: January 17, 2023
Page updated: March 20, 2023
Page reviewed: March 20, 2023
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