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Volume 29, Number 4—April 2023
Dispatch

Experimental Infection and Transmission of SARS-CoV-2 Delta and Omicron Variants among Beagle Dogs

Kwang-Soo Lyoo, Hanbyeul Lee, Sung-Geun Lee, Minjoo Yeom, Joo-Yeon Lee, Kyung-Chang Kim, Jeong-Sun Yang, and Daesub SongComments to Author 
Author affiliations: Jeonbuk National University, Iksan, South Korea (K-S. Lyoo, S.-G. Lee); Seoul National University, Seoul, South Korea (H. Lee, M. Yeom, D. Song); Korea Disease Control and Prevention Agency, Cheongju, South Korea (J.-Y. Lee, K.-C. Kim, J.-S. Yang)

Main Article

Figure 2

Pathologic changes in the lungs of dogs in study of experimental infection and transmission of SARS-CoV-2 Delta and Omicron variants among beagle dogs. A) Lung tissue from dog experimentally infected with Delta variant shows alveolar septa severely thickened by the infiltration of lymphocytes, macrophages, degenerate neutrophils, and karyorrhectic cellular debris. B) Lung tissue from naive (transmission) dog housed with Delta-infected dog shows alveolar septa thickened by the infiltration of numerous macrophages and lymphocytes, along with collagen accumulation. C) Lung tissue from dog experimentally infected with Omicron variant shows severe interstitial pneumonia and alveolar septal thickening due to the infiltration of lymphocytes, macrophages, and degenerate neutrophils. D) Lung tissue from naive (transmission) dog housed with Omicron-infected dog shows alveolar septa thickened by few macrophages, lymphocytes, and degenerate neutrophils. Original magnification ×400.

Figure 2. Pathologic changes in the lungs of dogs in study of experimental infection and transmission of SARS-CoV-2 Delta and Omicron variants among beagle dogs. A) Lung tissue from dog experimentally infected with Delta variant shows alveolar septa severely thickened by the infiltration of lymphocytes, macrophages, degenerate neutrophils, and karyorrhectic cellular debris. B) Lung tissue from naive (transmission) dog housed with Delta-infected dog shows alveolar septa thickened by the infiltration of numerous macrophages and lymphocytes, along with collagen accumulation. C) Lung tissue from dog experimentally infected with Omicron variant shows severe interstitial pneumonia and alveolar septal thickening due to the infiltration of lymphocytes, macrophages, and degenerate neutrophils. D) Lung tissue from naive (transmission) dog housed with Omicron-infected dog shows alveolar septa thickened by few macrophages, lymphocytes, and degenerate neutrophils. Original magnification ×400.

Main Article

Page created: January 11, 2023
Page updated: March 21, 2023
Page reviewed: March 21, 2023
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