Volume 29, Number 5—May 2023
Dispatch
Poor Prognosis for Puumala Virus Infections Predicted by Lymphopenia and Dyspnea
Stefan Hatzl, Florian Posch, Marina Linhofer, Stephan Aberle, Ines Zollner-Schwetz, Florian Krammer, and Robert Krause
Table
Baseline characteristics for patients according to clinical course and overall for poor prognosis for Puumala virus infections predicted by lymphopenia and dyspnea*
| Variable | Overall, n = 23 | Mild course, n = 18 | Severe course, n = 5 | p value |
|---|---|---|---|---|
| Demographic | ||||
| Age, y | 49 [34–59] | 51 [35–60] | 45 [24–49] | 0.087 |
| Female sex | 6 (26) | 5 (28) | 1 (20) | 1.000 |
| BMI, kg/m2 |
24.9 [23.6–26.8] |
24.8 [23.4–27.0] |
25.6 [24.8–26.1] |
0.433 |
| Comorbidity | ||||
| >1 |
5 (22) |
4 (22) |
1 (20) |
1.000 |
| Symptoms at diagnosis | ||||
| Headache | 17 (74) | 12 (66) | 5 (100) | 0.133 |
| Eye pain | 2 (9) | 2 (11) | 0 | 0.435 |
| Dyspnea | 3 (13) | 0 | 3 (60) | 0.001 |
| Body temperature | 39.5 [39.0–39.7] | 39.5 [39.2–39.7] | 39.4 [39.0–39.8] | 1.000 |
| Diarrhea | 3 (13) | 3 (17) | 0 | 0.328 |
| Abdominal cramps | 3 (13) | 2 (11) | 1 (20) | 0.602 |
| Blurred vision |
3 (13) |
3 (17) |
0 |
0.328 |
| Time from first symptom to diagnosis | 2 [1–3] | 2 [1–2] | 3 [1.3–3.8] | 0.047 |
| Predisposition to contact with rodents |
10 (44) |
7 (39) |
3 (60) |
0.040 |
| Laboratory values | ||||
| Creatinine, mg/dL | 1.2 [1.0–1.8] | 1.2 [1.0–1.9] | 1.2 [0.8–1.3] | 0.456 |
| CRP, mg/L | 60 [36–73] | 58 [42–63] | 73 [24–139] | 0.551 |
| LDH, IU | 266 [236–311] | 266 [236–312] | 258 [240–280] | 0.654 |
| Bilirubin total, mg/dL | 0.5 [0.3–0.8] | 0.3 [0.3–07] | 0.7 [0.6–0.9] | 0.107 |
| Prothrombin time, s | 105 [95–118] | 108 [105–120] | 94 [81–97] | 0.012 |
| APTT, s |
33 [31–37] |
33 [31–36] |
36 [35–41] |
0.147 |
| Blood counts | ||||
| Leukocytes, Gg/L | 9.9 [9.9‒11.8] | 9.0 [6.6–11.1] | 12.2 [9.1–13.9] | 0.371 |
| Neutrophils, G/L | 6.8 [4.1–10.7] | 6.3 [4.0–9.3] | 10.7 [7.0–12.1] | 0.168 |
| Lymphocytes, G/L | 1.0 [0.8–2.4] | 1.8 [0.9–2.4] | 0.3 [0.2–0.5] | <0.001 |
| Thrombocytes, G/L | 73 [50–130] | 63 [47–129] | 78 [73–129] | 0.911 |
| Hemoglobin, mg/dL |
14.5 [13.2–15.5] |
14.4 [13.2–15.4] |
15.5 [13.8–16.4] |
0.371 |
| Outcome | ||||
| Died |
1 (4) |
0 |
1 (20) |
0.483 |
| Length of stay in hospital, d | 7 [4–12] | 6 [3–9] | 15 [12–17] | 0.048 |
*Values in brackets are 25th–75th percentiles; values in parentheses are percentages. APPT, activated partial thromboplastin time; BMI, body mass index; CRP, C-reactive protein; G, giga; LDH, lactate dehydrogenase.
Page created: February 17, 2023
Page updated: April 25, 2023
Page reviewed: April 25, 2023
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