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Volume 29, Number 6—June 2023
Research

Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain

Cristina Rodríguez-Grande, Agustín Estévez, Rosalía Palomino-Cabrera, Andrea Molero-Salinas, Daniel Peñas-Utrilla, Marta Herranz, Amadeo Sanz-Pérez, Luis Alcalá, Cristina Veintimilla, Pilar Catalán, Carolina Martínez-Laperche, Roberto Alonso, Patricia Muñoz, Laura Pérez-Lago1Comments to Author , Darío García de Viedma1Comments to Author , and on behalf of the Gregorio Marañón Microbiology-ID COVID 19 Study Group2
Author affiliations: Gregorio Marañón General University Hospital, Madrid, Spain (C. Rodríguez-Grande, A. Estévez, R. Palomino-Cabrera, A. Molero-Salinas, D. Peñas-Utrilla, M. Herranz, A. Sanz-Pérez, L. Alcalá, C. Veintimilla, P. Catalán, C. Martínez-Laperche, R. Alonso, P. Muñoz, L. Pérez-Lago, D. García de Viedma); Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid (C. Rodríguez-Grande, A. Estévez, R. Palomino-Cabrera, A. Molero-Salinas, D. Peñas-Utrilla, A. Sanz-Pérez, L. Pérez-Lago, D. García de Viedma); Universidad Complutense, Madrid (R. Alonso, P. Muñoz); Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias-CIBERES, Madrid (R. Alonso, P. Muñoz, D. García de Viedma)

Main Article

Figure

Flowchart of case selection in a study of early SARS-CoV-2 reinfection involving the same or different genomic lineages, Spain. PCR-positive cases were diagnosed by our tertiary hospital, which covers 650,000 inhabitants in the population of Madrid. Among 26 cases with optimal coverage for WGS, 11 were reinfections (red boxes), 4 of which were non-Omicron to Omicron lineage reinfections. Probable reinfection cases (yellow boxes; patients 23–26) showed enough unique SNV differences between the sequences from their sequential specimens to be suspect of reinfection (Appendix Table 3). Ct, cycle threshold; SNV, single-nucleotide variants; WGS, whole-genome sequencing.

Figure. Flowchart of case selection in a study of early SARS-CoV-2 reinfection involving the same or different genomic lineages, Spain. PCR-positive cases were diagnosed by our tertiary hospital, which covers 650,000 inhabitants in the population of Madrid. Among 26 cases with optimal coverage for WGS, 11 were reinfections (red boxes), 4 of which were non-Omicron to Omicron lineage reinfections. Probable reinfection cases (yellow boxes; patients 23–26) showed enough unique SNV differences between the sequences from their sequential specimens to be suspect of reinfection (Appendix Table 3). Ct, cycle threshold; SNV, single-nucleotide variants; WGS, whole-genome sequencing.

Main Article

1This senior authors contributed equally to this article.

2Additional members of the Gregorio Marañón Microbiology-ID COVID-19 Study Group who contributed data are listed at the end of this article.

Page created: April 17, 2023
Page updated: May 17, 2023
Page reviewed: May 17, 2023
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