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Volume 29, Number 6—June 2023
Research

Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain

Cristina Rodríguez-Grande, Agustín Estévez, Rosalía Palomino-Cabrera, Andrea Molero-Salinas, Daniel Peñas-Utrilla, Marta Herranz, Amadeo Sanz-Pérez, Luis Alcalá, Cristina Veintimilla, Pilar Catalán, Carolina Martínez-Laperche, Roberto Alonso, Patricia Muñoz, Laura Pérez-Lago1Comments to Author , Darío García de Viedma1Comments to Author , and on behalf of the Gregorio Marañón Microbiology-ID COVID 19 Study Group2
Author affiliations: Gregorio Marañón General University Hospital, Madrid, Spain (C. Rodríguez-Grande, A. Estévez, R. Palomino-Cabrera, A. Molero-Salinas, D. Peñas-Utrilla, M. Herranz, A. Sanz-Pérez, L. Alcalá, C. Veintimilla, P. Catalán, C. Martínez-Laperche, R. Alonso, P. Muñoz, L. Pérez-Lago, D. García de Viedma); Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid (C. Rodríguez-Grande, A. Estévez, R. Palomino-Cabrera, A. Molero-Salinas, D. Peñas-Utrilla, A. Sanz-Pérez, L. Pérez-Lago, D. García de Viedma); Universidad Complutense, Madrid (R. Alonso, P. Muñoz); Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias-CIBERES, Madrid (R. Alonso, P. Muñoz, D. García de Viedma)

Main Article

Table 1

Clinical characteristics of patients with early SARS-CoV-2 reinfection involving the same or different genomic lineages, Spain*

Characteristics First episode, n = 11 Second episode, n = 11
Average age, y (range)
 43.27 (8–88)
 43.27 (8–88)
Sex
M 4 (36.36) 4 (36.36)
F
 7 (63.64)
 7 (63.64)
Illness severity
Asymptomatic 4 (36.36) 5 (45.45)
Mild 5 (45.45) 6 (54.55)
Intermediate 2 (18.18) 0
Severe
 0
 0
Care required
Emergency 0 0
Hospital admission 3 (27.27) 2 (18.18)
Hospital admission for 
COVID-19 2 (18.18) 0
Nosocomial transmission 1 (9.09) 0
ICU 0 0
ICU for COVID-19
 0
 0
Underlying conditions
None of interest 7 (63.64) 7 (63.64)
High blood pressure 3 (27.27) 3 (27.27)
COPD 1 (9.09) 1 (9.09)
Asthma 0 0
Diabetes 2 (18.18) 2 (18.18)
Ictus 2 (18.18) 2 (18.18)
Overweight/obesity 1 (9.09) 1 (9.09)
Heart disease 2 (18.18) 2 (18.18)
Autoimmune 1 (9.09) 1 (9.09)
Oncological 0 0
Chronic kidney disease 1 (9.09) 1 (9.09)
HIV infection 0 0
AIDS 0 0
Pregnant 0 0
Paxlovid use‡ 0 0
Use of dexamethasone
 0
 0
Death
 0
 0
Vaccines and serology
Complete vaccination 
schedule 6 (54.55) 6 (54.55)
Incomplete vaccination 
schedule 1 (9.09) 1 (9.09)
Unvaccinated 4 (36.36) 4 (36.36)
Previous positive serology 
for SARS-CoV-2 0 0
Previous negative serology 
for SARS-CoV-2 2 (18.18) 2 (18.18)
Serology not available 9 (81.82) 9 (81.82)

*Values are no. (%) except as indicated. COPD, chronic obstructive pulmonary disease; ICU, intensive care unit. †Illness severity was defined according to the following criteria: mild, general unrest, cough, diarrhea, cephalgia, fever, anosmia, myalgias, rhinorrhea; moderate, previous symptoms plus dyspnea, mild respiratory failure, or unilateral pneumonia; severe, previously listed symptoms plus bilateral pneumonia or severe respiratory failure. ‡Nirmatrelvir/ritonavir.

Main Article

1This senior authors contributed equally to this article.

2Additional members of the Gregorio Marañón Microbiology-ID COVID-19 Study Group who contributed data are listed at the end of this article.

Page created: April 17, 2023
Page updated: May 17, 2023
Page reviewed: May 17, 2023
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