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Volume 29, Number 6—June 2023
Research

Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain

Cristina Rodríguez-Grande, Agustín Estévez, Rosalía Palomino-Cabrera, Andrea Molero-Salinas, Daniel Peñas-Utrilla, Marta Herranz, Amadeo Sanz-Pérez, Luis Alcalá, Cristina Veintimilla, Pilar Catalán, Carolina Martínez-Laperche, Roberto Alonso, Patricia Muñoz, Laura Pérez-Lago1Comments to Author , Darío García de Viedma1Comments to Author , and on behalf of the Gregorio Marañón Microbiology-ID COVID 19 Study Group2
Author affiliations: Gregorio Marañón General University Hospital, Madrid, Spain (C. Rodríguez-Grande, A. Estévez, R. Palomino-Cabrera, A. Molero-Salinas, D. Peñas-Utrilla, M. Herranz, A. Sanz-Pérez, L. Alcalá, C. Veintimilla, P. Catalán, C. Martínez-Laperche, R. Alonso, P. Muñoz, L. Pérez-Lago, D. García de Viedma); Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid (C. Rodríguez-Grande, A. Estévez, R. Palomino-Cabrera, A. Molero-Salinas, D. Peñas-Utrilla, A. Sanz-Pérez, L. Pérez-Lago, D. García de Viedma); Universidad Complutense, Madrid (R. Alonso, P. Muñoz); Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias-CIBERES, Madrid (R. Alonso, P. Muñoz, D. García de Viedma)

Main Article

Table 3

Clinical characteristics of cases without short-term SARS-CoV-2 persistence in a study of early SARS-CoV-2 reinfection involving the same or different genomic lineages, Spain*

Characteristic Value, n = 11
Average age, y (range)
 58.5 (1–94)
Sex
M 4 (36.4)
F
 7 (63.6)
Illness severity
Asymptomatic 2 (18.2)
Mild 4 (36.4)
Intermediate 2 (18.2)
Severe
 2 (18.2)
Care required
Emergency 1 (9.1)
Hospital admission 6 (54.5)
Hospital admission for COVID-19 3 (27.3)
Nosocomial transmission 1 (9.1)
ICU 0
ICU for COVID-19
 0
Underlying conditions
None of interest 3 (27.3)
High blood pressure 6 (54.5)
COPD 2 (18.2)
Asthma 1 (9.1)
Diabetes 0
Ictus 1 (9.1)
Overweight/obesity 6 (54.5)
Heart disease 5 (45.5)
Autoimmune 3 (27.3)
Oncological 2 (18.2)
Chronic kidney disease 2 (18.2)
HIV infection 1 (9.1)
AIDS 0
Pregnant 0
Paxlovid use‡ 1 (9.1)
Remdesivir use 3 (27.3)
Tocilizumab use 1 (9.1)
Dexamethasone use
 4 (36.4)
Death
 1 (9.1)
Vaccines and serology
Complete vaccination schedule 8 (72.7)
Incomplete vaccination schedule 1 (9.1)
Unvaccinated 2 (18.2)
Previous positive serology for SARS-CoV-2 3 (27.3)
Previous negative serology for SARS-CoV-2 2 (18.2)
Serology not available 6 (54.5)

*Values are no. (%) except as indicated. COPD, chronic obstructive pulmonary disease; ICU, intensive care unit. †Illness severity was defined according to the following criteria: mild, general unrest, cough, diarrhea, cephalgia, fever, anosmia, myalgias, rhinorrhea; moderate, previous symptoms plus dyspnea, mild respiratory failure, or unilateral pneumonia; severe, previously listed symptoms plus bilateral pneumonia or severe respiratory failure. ‡Nirmatrelvir/ritonavir.

Main Article

1This senior authors contributed equally to this article.

2Additional members of the Gregorio Marañón Microbiology-ID COVID-19 Study Group who contributed data are listed at the end of this article.

Page created: April 17, 2023
Page updated: May 17, 2023
Page reviewed: May 17, 2023
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