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Volume 29, Number 6—June 2023
Dispatch

Novel Avian Influenza Virus (H5N1) Clade 2.3.4.4b Reassortants in Migratory Birds, China

Jing Yang1, Chunge Zhang1, Yue Yuan1, Ju Sun1, Lu Lu1, Honglei Sun, Heting Sun, Dong Chu, Siyuan Qin, Jianjun Chen, Chengbo Zhang, Xiyan Hao, Weifeng Shi, Wenjun Liu, George F. Gao, Paul Digard, Samantha Lycett, and Yuhai BiComments to Author 
Author affiliations: Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences–The World Academy of Sciences Center of Excellence for Emerging Infectious Diseases, Chinese Academy of Sciences, Beijing, China (J. Yang, Chunge Zhang, J. Sun, W. Liu, G.F. Gao, Y. Bi); University of Chinese Academy of Sciences, Beijing (J. Yang, Chunge Zhang, W. Liu, G.F. Gao, Y. Bi); Shandong First Medical University, Taian, China (Y. Yuan, W. Shi, Y. Bi); Shanxi Agricultural University, Taigu, China (J. Sun, Y. Bi); University of Edinburgh, Edinburgh, UK (L. Lu, P. Digard, S. Lycett); China Agricultural University, Beijing (Honglei Sun); State Forestry and Grassland Administration, Shenyang, China (Heting Sun, D. Chu, S. Qin); Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China (J. Chen); Ordos Forestry and Grassland Development Center, Ordos, China (Chengbo Zhang); Hohhot Center for Disease Control and Prevention, Hohhot, China (X. Hao)

Main Article

Table 2

Amino acid substitutions on the hemagglutinin antigenic sites between H5N1 2021 and H5N8 2020 highly pathogenic avian influenza viruses and H5 vaccine seed viruses Re-11, Re-13, and Re-14 used in China*

Virus Position of antigenic sites in hemagglutinin genes (H3 numbering)*
63 81 125 131 132 144 145 155 158 159 160 166 188 189 193 202
Re-11, clade2344h D R R T S V A T N D A M A E N V
Re-13, clade2344h N S E T T V A T N E T K V E D V
Re-14, clade2344b D R S E T A P I N D A I A E N I
Bs/EC/74-Lg/2021(H5N1) D R N E T A P I N D A I A K D I
Ws/NC/AK1-O/2021(H5N1) D R S E T A P I D D A I A K N I
Ws/NC/AK2-O/2021(H5N1) D R S E T A P I D D A I A K N I
Ws/HN/1-K/2020(H5N8) D R S E T A P I N D A I A E N I
Ws/HN/1-G/2020(H5N8) D R S E T A P I N D A I A E N I
Ws/HN/2-F17/2020(H5N8) D R S E T A P I N D A I A E N I
Ws/HN/2-F18/2020(H5N8) D R S E T A P I N D A I A E N I

*Positions of antigenic sites based on the H5 and H3 (sites A–E) antigenic sites.

Main Article

1These authors contributed equally to this article.

Page created: April 17, 2023
Page updated: May 17, 2023
Page reviewed: May 17, 2023
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