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Volume 29, Number 6—June 2023
Dispatch

Novel Avian Influenza Virus (H5N1) Clade 2.3.4.4b Reassortants in Migratory Birds, China

Jing Yang1, Chunge Zhang1, Yue Yuan1, Ju Sun1, Lu Lu1, Honglei Sun, Heting Sun, Dong Chu, Siyuan Qin, Jianjun Chen, Chengbo Zhang, Xiyan Hao, Weifeng Shi, Wenjun Liu, George F. Gao, Paul Digard, Samantha Lycett, and Yuhai BiComments to Author 
Author affiliations: Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences–The World Academy of Sciences Center of Excellence for Emerging Infectious Diseases, Chinese Academy of Sciences, Beijing, China (J. Yang, Chunge Zhang, J. Sun, W. Liu, G.F. Gao, Y. Bi); University of Chinese Academy of Sciences, Beijing (J. Yang, Chunge Zhang, W. Liu, G.F. Gao, Y. Bi); Shandong First Medical University, Taian, China (Y. Yuan, W. Shi, Y. Bi); Shanxi Agricultural University, Taigu, China (J. Sun, Y. Bi); University of Edinburgh, Edinburgh, UK (L. Lu, P. Digard, S. Lycett); China Agricultural University, Beijing (Honglei Sun); State Forestry and Grassland Administration, Shenyang, China (Heting Sun, D. Chu, S. Qin); Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China (J. Chen); Ordos Forestry and Grassland Development Center, Ordos, China (Chengbo Zhang); Hohhot Center for Disease Control and Prevention, Hohhot, China (X. Hao)

Main Article

Table 1

HI titers of H5N1 and H5N8 highly pathogenic avian influenza viruses from wild birds in China against antiserum of H5 Re-11, Re-13, and Re-14 vaccines*

Virus HI titers of chicken antiserum against vaccine strains and H5N1/H5N8 isolates
Re-11, clade2.3.4.4h Re-13, clade2.3.4.4h Re-14, clade2.3.4.4b
Re-11, Dk/GZ/S4184/2017(H5N6) 256 256–512 128
Re-13, Dk/FJ/S1424/2020(H5N6) 32 256 2–4
Re-14, Ws/SX/4–1/2020(H5N8) 8 16 256
Bs/EC/74-Lg/2021(H5N1) 16 8 128
Ws/NC/AK2-O/2021(H5N1) 2–4 2–4 32
Ws/HN/1-K/2020(H5N8) 8 8 64
Ws/HN/1-G/2020(H5N8) 8 8 64

*H5 Re-11 vaccine was used in poultry in mainland China during December 2018–December 2021. H5 Re-13 and Re-14 vaccines have been deployed since January 2022. HI, hemagglutination inhibition.

Main Article

1These authors contributed equally to this article.

Page created: April 17, 2023
Page updated: May 17, 2023
Page reviewed: May 17, 2023
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