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Volume 29, Number 6—June 2023
CME ACTIVITY - Synopsis

Neurologic Complications of Babesiosis, United States, 2011–2021

Sara Locke1, Jane O’Bryan1, Adeel S. Zubair, Melissa Rethana, Anne Spichler Moffarah, Peter J. Krause2, and Shelli F. Farhadian2Comments to Author 
Author affiliations: Yale School of Medicine, New Haven, Connecticut, USA (S. Locke, J. O’Bryan, A.S. Zubair, M. Rethana, A. Spichler Moffarah, P.J. Krause, S.F. Farhadian); Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut, USA (J. O’Bryan); Yale School of Public Health, New Haven (P.J. Krause, S.F. Farhadian).

Main Article

Table 4

Associations between comorbid conditions and neurologic symptoms in patients with babesiosis admitted to Yale-New Haven Hospital, New Haven, Connecticut, USA, January 2011–October 2021*

Comorbid condition
 Confusion/delirium, no. (%)
 Adjusted odds of confusion/delirium
 Impaired consciousness, no. (%)
 Adjusted odds of impaired consciousness
OR (95% CI)
 p value
 OR (95% CI)
 p value
Diabetes mellitus
No 140 (13.6) 1.00 140 (10.7)
Yes
 23 (34.8)
 3.04 (1.11–8.34)
 0.031
 23 (39.1)
 5.36 (1.98–14.48)
 <0.001
Stroke/transient ischemic attack
No 150 (14.7)
Yes 13 (38.5) 3.06 (0.88–10.66) 0.079

*Univariate logistic regression models tested associations between the following comorbid conditions and the 3 most frequent neurologic symptoms (headache, confusion/delirium, impaired consciousness): cardiac disorder, hypertension, diabetes mellitus, immunocompromised status, stroke/transient ischemic attack, obesity, chronic kidney disease, migraine, and malignancy. Variables that were significant in unadjusted univariate analysis were entered into a multivariate model for each neurologic symptom. The significance level for univariate and multivariate analysis was set to p<0.05. Boldface indicates statistical significance.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: April 13, 2023
Page updated: May 19, 2023
Page reviewed: May 19, 2023
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