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Volume 29, Number 6—June 2023
CME ACTIVITY - Synopsis

Neurologic Complications of Babesiosis, United States, 2011–2021

Sara Locke1, Jane O’Bryan1, Adeel S. Zubair, Melissa Rethana, Anne Spichler Moffarah, Peter J. Krause2, and Shelli F. Farhadian2Comments to Author 
Author affiliations: Yale School of Medicine, New Haven, Connecticut, USA (S. Locke, J. O’Bryan, A.S. Zubair, M. Rethana, A. Spichler Moffarah, P.J. Krause, S.F. Farhadian); Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut, USA (J. O’Bryan); Yale School of Public Health, New Haven (P.J. Krause, S.F. Farhadian).

Main Article

Table 3

Laboratory result comparisons by neurologic symptoms in patients with babesiosis admitted to Yale-New Haven Hospital, New Haven, Connecticut, USA, January 2011–October 2021*

Laboratory result, median (IQR) Reference range Headache
 Confusion/delirium
 Impaired consciousness
Yes, 
n = 52 No, 
n = 111 p value† Yes, 
n = 27 No, 
n = 136 p value† Yes, 
n = 24 No, 
n = 139 p value†
Hematologic function
Lowest hematocrit M, 40%–52%; 
F, 37%–53% 25.9 (16.2–35.6) 26.0 (19.4­–32.6) 0.581 24.0 (16.5–31.5) 26.4 (18.8–34) 0.088 23.6 (15.7–31.5) 26.4 (18.9–33.9) 0.024
Lowest platelet count
 150–400 × 109/L
 78.5
(4.0–153.0)
 82.0 (23.0–141.0)
 0.881
68.0
(1.0–135.0)
 82.0
(−5.0 to 230.0)
 0.339
59.5
(−5.0 to 124.0)
 84.0 (17.0–151.0)
 0.084
Hepatic function
Highest AST 3–40 U/L 66.0 (25.5–106.5) 76.0 (38.0–114.0) 0.277 76.0 (42.0–110.0) 75.5 (32.5–118.5) 0.813 81.0 (48.0–114.0) 75.0 (33.0–117.0) 0.909
Highest ALT
 3–40 U/L
 61.0 (10.0–112.0)
 63.0
(9.0–117.0)
 0.809
54.0
(8.0–100.0)
 63.5 (12.5–114.5)
 0.568
49.0
(4.0–102.0)
 63.0 (13.0–113.0)
 0.441
Renal function
Highest BUN 7–20 mg/dL 17.0 (4.5–29.5) 24.0
(5.0–43.0)		 0.002 31.0
(−3.0 to 65.0)		 20.0 (5.5–34.5) 0.025 33.0
(0.0–66.0)		 20.0 (5.0–35.0) 0.005
Highest creatinine 0.5–1.2 mg/dL 1.00 (0.96–1.40) 1.1 (0.3–1.9) 0.091 1.5 (0.7–2.3) 1.0 (0.5–1.5) <0.001 1.5 (0.3–2.7) 1.0 (0.5–1.5) 0.002
Lowest GFR ≥60 mL/min 76.0 (37.5–114.5) 67.0 (21.0–113.0) 0.007 46.0 (3.0–89.0) 73.0 (33.5–112.5) <0.001 47.0 (1.0–93.0) 73.0 (33.0–113.0) 0.003

*Boldface indicates significance. ALT, alanine transaminase; AST, aspartate transaminase; BUN, blood urea nitrogen; GFR, glomerular filtration rate; IQR, interquartile range. †By Wilcoxon 2-sample test.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

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Page updated: May 19, 2023
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