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Volume 30, Number 10—October 2024
Research

Pathogenicity of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Cats in Mice and Ferrets, South Korea, 2023

Il-Hwan Kim1, Jeong-Hyun Nam1, Chi-Kyeong Kim, Yong Jun Choi, Hyeokjin Lee, Bo Min An, Nam-Joo Lee, Hyoseon Jeong, Su-Yeon Lee, Sang-Gu Yeo, Eun-Kyoung Lee, Youn-Jeong Lee, Jee Eun Rhee, Sang Won Lee, Youngmee Jee, and Eun-Jin KimComments to Author 
Author affiliations: Korea Disease Control and Prevention Agency, Cheongju, South Korea (I.-H. Kim, J.-H. Nam, C.-K. Kim, Y.J. Choi, H. Lee, B.M. An, N.-J. Lee, H. Jeong, S.-Y. Lee, S.-G. Yeo, J.E. Rhee, S.W. Lee, Y. Jee, E.-J. Kim); Animal and Plant Quarantine Agency, Gimcheon, South Korea (E.-K. Lee, Y.-J. Lee)

Main Article

Figure 6

Virus titers after ferret-to-ferret contact transmission in study of pathogenicity of highly pathogenic avian influenza A(H5N1) viruses isolated from cats, South Korea, 2023. Virus titers were measured in nasal washes from ferrets initially inoculated with virus (A) and naive ferrets exposed to the infected ferret (B). Viruses were isolated from 2 cats (YS/2023 and GA/2023) and 1 duck (YC/2022). We intranasally inoculated 1 ferret with 1 mL of 103 50% median lethal dose of each virus (1 ferret/virus) and then housed serologically naive ferrets (n = 2) in the same cage the next day (1 cage/virus). To evaluate transmission of virus to naive animals, nasal wash samples were collected over time, and virus titers were measured. GA/2023, A/feline/Korea/M305-7/2023; TCID50, 50% tissue culture infectious dose; YC/2022, A/duck/Korea/H493/2022; YS/2023, A/feline/Korea/M302-6/2023.

Figure 6. Virus titers after ferret-to-ferret contact transmission in study of pathogenicity of highly pathogenic avian influenza A(H5N1) viruses isolated from cats, South Korea, 2023. Virus titers were measured in nasal washes from ferrets initially inoculated with virus (A) and naive ferrets exposed to the infected ferret (B). Viruses were isolated from 2 cats (YS/2023 and GA/2023) and 1 duck (YC/2022). We intranasally inoculated 1 ferret with 1 mL of 103 50% median lethal dose of each virus (1 ferret/virus) and then housed serologically naive ferrets (n = 2) in the same cage the next day (1 cage/virus). To evaluate transmission of virus to naive animals, nasal wash samples were collected over time, and virus titers were measured. GA/2023, A/feline/Korea/M305-7/2023; TCID50, 50% tissue culture infectious dose; YC/2022, A/duck/Korea/H493/2022; YS/2023, A/feline/Korea/M302-6/2023.

Main Article

1These authors contributed equally to this article.

Page created: August 21, 2024
Page updated: September 23, 2024
Page reviewed: September 23, 2024
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