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Volume 30, Number 10—October 2024
Research
Pathogenicity of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Cats in Mice and Ferrets, South Korea, 2023
Figure 2
![Virus titers in organs of mice infected with highly pathogenic avian influenza A(H5N1) viruses isolated from cats in South Korea, 2023. Viruses were isolated from 2 cats (YS/2023 and GA/2023) and 1 duck (YC/2022). BALB/c mice (n = 15/virus) were inoculated with 50 µL of 103 50% median lethal dose/mL of each virus; 5 mice/day from each virus group were euthanized on days 3 (A), 5 (B), and 7 (C) postinfection to measure and compare virus titers in organ tissues. GA/2023 virus titers were not measured on day 7 because all of those mice died by day 6 postinfection. p values were calculated by using 2-way analysis of variance. dpi, days postinoculation; GA/2023, A/feline/Korea/M305-7/2023; TCID50, 50% tissue culture infectious dose; YC/2022, A/duck/Korea/H493/2022; YS/2023, A/feline/Korea/M302-6/2023.](/eid/images/24-0583-F2.jpg)
Figure 2. Virus titers in organs of mice infected with highly pathogenic avian influenza A(H5N1) viruses isolated from cats in South Korea, 2023. Viruses were isolated from 2 cats (YS/2023 and GA/2023) and 1 duck (YC/2022). BALB/c mice (n = 15/virus) were inoculated with 50 µL of 103 50% median lethal dose/mL of each virus; 5 mice/day from each virus group were euthanized on days 3 (A), 5 (B), and 7 (C) postinfection to measure and compare virus titers in organ tissues. GA/2023 virus titers were not measured on day 7 because all of those mice died by day 6 postinfection. p values were calculated by using 2-way analysis of variance. dpi, days postinoculation; GA/2023, A/feline/Korea/M305-7/2023; TCID50, 50% tissue culture infectious dose; YC/2022, A/duck/Korea/H493/2022; YS/2023, A/feline/Korea/M302-6/2023.
1These authors contributed equally to this article.