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Volume 30, Number 10—October 2024
Research

Pathogenicity of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Cats in Mice and Ferrets, South Korea, 2023

Il-Hwan Kim1, Jeong-Hyun Nam1, Chi-Kyeong Kim, Yong Jun Choi, Hyeokjin Lee, Bo Min An, Nam-Joo Lee, Hyoseon Jeong, Su-Yeon Lee, Sang-Gu Yeo, Eun-Kyoung Lee, Youn-Jeong Lee, Jee Eun Rhee, Sang Won Lee, Youngmee Jee, and Eun-Jin KimComments to Author 
Author affiliations: Korea Disease Control and Prevention Agency, Cheongju, South Korea (I.-H. Kim, J.-H. Nam, C.-K. Kim, Y.J. Choi, H. Lee, B.M. An, N.-J. Lee, H. Jeong, S.-Y. Lee, S.-G. Yeo, J.E. Rhee, S.W. Lee, Y. Jee, E.-J. Kim); Animal and Plant Quarantine Agency, Gimcheon, South Korea (E.-K. Lee, Y.-J. Lee)

Main Article

Figure 2

Virus titers in organs of mice infected with highly pathogenic avian influenza A(H5N1) viruses isolated from cats in South Korea, 2023. Viruses were isolated from 2 cats (YS/2023 and GA/2023) and 1 duck (YC/2022). BALB/c mice (n = 15/virus) were inoculated with 50 µL of 103 50% median lethal dose/mL of each virus; 5 mice/day from each virus group were euthanized on days 3 (A), 5 (B), and 7 (C) postinfection to measure and compare virus titers in organ tissues. GA/2023 virus titers were not measured on day 7 because all of those mice died by day 6 postinfection. p values were calculated by using 2-way analysis of variance. dpi, days postinoculation; GA/2023, A/feline/Korea/M305-7/2023; TCID50, 50% tissue culture infectious dose; YC/2022, A/duck/Korea/H493/2022; YS/2023, A/feline/Korea/M302-6/2023.

Figure 2. Virus titers in organs of mice infected with highly pathogenic avian influenza A(H5N1) viruses isolated from cats in South Korea, 2023. Viruses were isolated from 2 cats (YS/2023 and GA/2023) and 1 duck (YC/2022). BALB/c mice (n = 15/virus) were inoculated with 50 µL of 103 50% median lethal dose/mL of each virus; 5 mice/day from each virus group were euthanized on days 3 (A), 5 (B), and 7 (C) postinfection to measure and compare virus titers in organ tissues. GA/2023 virus titers were not measured on day 7 because all of those mice died by day 6 postinfection. p values were calculated by using 2-way analysis of variance. dpi, days postinoculation; GA/2023, A/feline/Korea/M305-7/2023; TCID50, 50% tissue culture infectious dose; YC/2022, A/duck/Korea/H493/2022; YS/2023, A/feline/Korea/M302-6/2023.

Main Article

1These authors contributed equally to this article.

Page created: August 21, 2024
Page updated: September 23, 2024
Page reviewed: September 23, 2024
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