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Volume 30, Number 10—October 2024
Research

Pathogenicity of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Cats in Mice and Ferrets, South Korea, 2023

Il-Hwan Kim1, Jeong-Hyun Nam1, Chi-Kyeong Kim, Yong Jun Choi, Hyeokjin Lee, Bo Min An, Nam-Joo Lee, Hyoseon Jeong, Su-Yeon Lee, Sang-Gu Yeo, Eun-Kyoung Lee, Youn-Jeong Lee, Jee Eun Rhee, Sang Won Lee, Youngmee Jee, and Eun-Jin KimComments to Author 
Author affiliations: Korea Disease Control and Prevention Agency, Cheongju, South Korea (I.-H. Kim, J.-H. Nam, C.-K. Kim, Y.J. Choi, H. Lee, B.M. An, N.-J. Lee, H. Jeong, S.-Y. Lee, S.-G. Yeo, J.E. Rhee, S.W. Lee, Y. Jee, E.-J. Kim); Animal and Plant Quarantine Agency, Gimcheon, South Korea (E.-K. Lee, Y.-J. Lee)

Main Article

Table 3

Susceptibility of highly pathogenic avian influenza A(H5N1) viruses isolated from cats in South Korea, 2023, to antiviral drugs*

Virus Subtype Neuraminidase inhibitors
Oseltamivir
 Zanamivir
 Peramivir
IC50, nM Fold change IC50, nM Fold change IC50, nM Fold change
A/duck/Korea/H493/2022 H5N1 0.16 0.11 0.19 0.18 0.44 0.775
A/feline/Korea/M302-6/2023 H5N1 0.35 0.24 0.18 0.17 0.2 0.3
A/feline/Korea/M305–-/2023 H5N1 0.23 0.15 0.16 0.15 0.2 0.36
Influenza A(H1N1)pdm09 H1N1 1.47 1 1.09 1 0.57 1

*H5N1 virus from 1 duck was compared with 2 viruses isolated from cats. Fold change in drug susceptibility was measured relative to that of influenza A(H1N1)pdm09 containing the wild-type H274 amino acid in neuraminidase. IC50, 50% inhibitory concentration.

Main Article

1These authors contributed equally to this article.

Page created: August 21, 2024
Page updated: September 06, 2024
Page reviewed: September 06, 2024
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