Volume 30, Number 11—November 2024
Research
Antiviral Susceptibility of Swine-Origin Influenza A Viruses Isolated from Humans, United States
Rongyuan Gao1, Philippe Noriel Q. Pascua1, Anton Chesnokov, Ha T. Nguyen, Timothy M. Uyeki, Vasiliy P. Mishin, Natosha Zanders, Dan Cui, Yunho Jang, Joyce Jones, Juan De La Cruz, Han Di, Charles Todd Davis, and Larisa V. Gubareva
Table 3
Neutralization of variant viruses by broadly reactive human mAbs in IRINA in study of antiviral susceptibility of swine-origin influenza A viruses isolated from humans, United States*
| Influenza viruses | HA clade | Mean EC50 + SD, µg/mL |
HA Acc. ID† | |
|---|---|---|---|---|
| FI6v3 | CR9114 | |||
| A(H1N1)v, n = 7 | ||||
| A/California/07/2009 | 1A.3.3.2 | >10 | 3.39 + 0.74 | EPI1161425 |
| A/North Carolina/01/2021 | 1A.3.3.2 | 1.83 + 0.35 | 0.48 + 0.14 | EPI1869574 |
| A/North Dakota/12226/2021 | 1A.3.3.c-c1 | 7.91 + 1.33 | 1.81 + 0.25 | EPI1918841 |
| A/Missouri/12/2012 | 1A.3.3.3-c3 | 2.15 + 0.15 | 0.62 + 0.06 | EPI395313 |
| A/Arkansas/14/2013 | 1A.3.3.3-c3 | 7.79 + 0.35 | 2.89 + 0.18 | EPI471102 |
| A/Arkansas/15/2013 | 1A.3.3.3-c3 | 4.52 + 0.94 | 1.38 + 0.18 | EPI482785 |
| A/Wisconsin/03/2021 |
1A.3.3.3-c3 |
1.18 + 0.20 |
0.55 + 0.02 |
EPI1868840 |
| A(H1N2)v, n = 7 | ||||
| A/Ohio/24/2017 | 1A.1.1.3 | >10 | 5.31 + 0.66 | EPI1056725 |
| A/Pennsylvania/27/2024 | 1A.1.1.3 | 1.46 + 0.06 | 1.01 + 0.04 | EPI3171496 |
| A/Michigan/382/2018 | 1B.2.1 | >10 | 4.02 + 1.73 | EPI1271034 |
| A/Ohio/35/2017 | 1B.2.1 | 0.15 + 0.01 | 0.16 +0.03 | EPI1056733 |
| A/Iowa/04/2021 | 1B.2.1 | 0.03 + 0.01 | 0.03 + 0.01 | EPI3215541 |
| A/Ohio/28/2022 | 1B.2.1 | 3.72 + 0.36 | 1.33 + 0.06 | EPI2193021 |
| A/Michigan/48/2023 |
1B.2.1 |
5.75 + 2.24 |
1.33 + 0.24 |
EPI2687008 |
| A(H3N2)v, n = 8 | ||||
| A/Hawaii/28/2020 | 1990.1 | >10 | >10 | EPI1804523 |
| A/Iowa/04/2013 | 1990.4.a | 5.94 + 1.25 | 2.26 +1.23 | EPI516844 |
| A/Wisconsin/24/2014 | 1990.4.a | >10 | >10 | EPI557542 |
| A/Michigan/39/2015 | 1990.4.a | >10 | >10 | EPI642513 |
| A/Ohio/02/2014 | 1990.4.b1 | >10 | 6.59 + 1.37 | EPI539159 |
| A/Ohio/27/2016 | 2010.1 | 5.82 + 2.38 | >10 | EPI881739 |
| A/Ohio/13/2017 | 2010.1 | 2.30 + 0.54 | >10 | EPI1056653 |
| A/Wisconsin/01/2021 |
2010.1 |
0.64 + 0.11 |
4.48 + 0.40 |
EPI1843130 |
| Reference seasonal viruses‡ | ||||
| A/Illinois/08/2018 (H1N1)pdm09 | N/A | 8.29 + 1.11 | 1.69 + 0.07 | EPI1259741 |
| A/Louisiana/50/2017 (H3N2) | N/A | 6.41 + 1.29 | >10 | EPI1259757 |
*Each virus was tested in >3 independent experiments to determine EC50. EC50, 50% effective concentration; HA, hemagglutinin; IRINA, influenza replication inhibition neuraminidase-based assay; N/A, not applicable. †Accession number of HA sequences deposited to the GISAID database (https://gisaid.org) (accessed on April, 2024). ‡Source: Centers for Disease Control and Prevention antiviral susceptibility reference virus panels (FR-1678 ver1.1) (https://www.isirv.org/site/index.php/reference-panel).
1These authors contributed equally to this article.
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