Volume 30, Number 11—November 2024
Research
Antiviral Susceptibility of Swine-Origin Influenza A Viruses Isolated from Humans, United States
Rongyuan Gao1, Philippe Noriel Q. Pascua1, Anton Chesnokov, Ha T. Nguyen, Timothy M. Uyeki, Vasiliy P. Mishin, Natosha Zanders, Dan Cui, Yunho Jang, Joyce Jones, Juan De La Cruz, Han Di, Charles Todd Davis, and Larisa V. Gubareva
Table 4
Antigenic analysis of A(H1N2)v viruses with ferret antiserum using HI and IRINA in study of antiviral susceptibility of swine-origin influenza A viruses isolated from humans, United States*
| Influenza viruses | Ferret antiserum, titer (fold change) |
|||||||
|---|---|---|---|---|---|---|---|---|
| A/Ohio/35/2017 |
A/Michigan/48/2023 |
A/Victoria/2570/2019 |
||||||
| HI | IRINA | HI | IRINA | HI | IRINA | |||
| A(H1N2)v, clade 1B.2.1 | ||||||||
| A/Ohio/35/2017, CVV |
2,560 (1) |
29,041 (1) |
20 (64) |
228 (79) |
<10 |
<80 |
||
| Test viruses | ||||||||
| A/Michigan/383/2018 | 320 (8) | 1,131 (26) | 80 (16) | 469 (38) | <10 | <80 | ||
| A/Iowa/04/2021 | 640 (4) | 3,290 (9) | 160 (8) | 620 (29) | <10 | <80 | ||
| A/Ohio/28/2022 | 160 (16) | 1,542 (19) | 640 (2) | 11,677 (2) | <10 | <80 | ||
| A/Montana/28/2023 | 80 (32) | 252 (115) | 2,560 (1) | 21,399 (1) | <10 | <80 | ||
| A/Michigan/48/2023 |
40 (64) |
201 (144) |
1,280 (1) |
17,987 (1) |
<10 |
<80 |
||
| Reference seasonal A(H1N1)pdm09 | ||||||||
| A/Victoria/2570/2019, CVV | 160 (16) | 1,269 (23) | <10 | 134 (134) | 5,120 (1) | 81,920 (1) | ||
*HI titer determined using conventional method. IRINA titer determined using curve-fitting, 50% neutralization. Titers are reciprocal of antiserum dilution factor. Underlined values are reactivity titers of antiserum to homologous virus antigens. CVV, candidate vaccine virus; HI, hemagglutination inhibition; IRINA, influenza replication inhibition neuraminidase-based assay.
1These authors contributed equally to this article.
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