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Volume 30, Number 12—December 2024

Dispatch

Lack of Lloviu Virus Disease Development in Ferret Model

Paige Fletcher, Kyle L. O’Donnell, Joseph F. Rhoderick, Corey W. Henderson, Atsushi Okumura, Trenton Bushmaker, Ayato Takada, Chad S. Clancy, Gábor Kemenesi, and Andrea MarziComments to Author 
Author affiliation: National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA (P. Fletcher, K.L. O’Donnell, J.F. Rhoderick, C.W. Henderson, A. Okumura, T. Bushmaker, C.S. Clancy, A. Marzi); Hokkaido University, Sapporo, Japan (A. Takada); University of Pécs, Pécs, Hungary (G. Kemenesi)

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Figure 1

Clinical findings after experimental LLOV exposure in ferrets. Ferrets were inoculated through IM, IN, or aerosol (n = 6/group) routes with 1,000 focus-forming units of LLOV. A) Survival curve. B) Bodyweight percentage; dotted line is normalized to day of infection; error bars indicate standard error of the mean. C) Transponder temperature beginning at 1 day postinfection; error bars indicate standard error of the mean. D) LLOV glycoprotein-specific IgG titers in serum measured by ELISA. Dotted line indicates the limit of detection; error bars indicate standard error of the mean. IM, intramuscular; IN, intranasal; LLOV, Lloviu virus.

Figure 1. Clinical findings after experimental LLOV exposure in ferrets. Ferrets were inoculated through IM, IN, or aerosol (n = 6/group) routes with 1,000 focus-forming units of LLOV. A) Survival curve. B) Bodyweight percentage; dotted line is normalized to day of infection; error bars indicate standard error of the mean. C) Transponder temperature beginning at 1 day postinfection; error bars indicate standard error of the mean. D) LLOV glycoprotein-specific IgG titers in serum measured by ELISA. Dotted line indicates the limit of detection; error bars indicate standard error of the mean. IM, intramuscular; IN, intranasal; LLOV, Lloviu virus.

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Page created: November 01, 2024
Page updated: November 26, 2024
Page reviewed: November 26, 2024
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