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Volume 30, Number 2—February 2024
Research

Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil

Marcia da Costa Castilho, Ana Maria Bispo de Filippis, Lais Ceschini Machado, Thaise Yasmine Vasconcelos de Lima Calvanti, Morganna Costa Lima, Vagner Fonseca, Marta Giovanetti, Cassia Docena, Armando Menezes Neto, Camila Helena Aguiar Bôtto-Menezes, Edna Oliveira Kara, Rafael de La Barrera, Kayvon Modjarrad, Silvana Pereira Giozza, Gerson Fernando Pereira, Luiz Carlos Junior Alcantara, Nathalie Jeanne Nicole Broutet, Guilherme Amaral Calvet1, Gabriel Luz Wallau1, and Rafael Freitas Oliveira Franca1Comments to Author 
Author affiliations: Tropical Medicine Foundation Doctor Heitor Vieira Dourado, Manaus, Brazil (M. da Costa Castilho, C.H.A. Bôtto-Menezes); Oswaldo Cruz Foundation, Rio de Janeiro, Brazil (A.M.B. de Filippis, M. Giovanetti, L.C.J. Alcantara); Oswaldo Cruz Foundation, Recife, Brazil (L.C. Machado, T.Y.V. de L. Calvanti, M.C. Lima, C. Docena, A.M. Neto, G.A. Calvet, G.L. Wallau, R.F.O. Franca); Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, Brazil (V. Fonseca); University of Campus Bio-Medico di Roma, Rome, Italy (M. Giovanetti); World Health Organization, Geneva, Switzerland (E.O. Kara, N.J.N. Broutet); Walter Reed Army Institute of Research, Silver Spring, Maryland, USA (R. de La Barrera, K. Modjarrad); Department of Chronic Condition Diseases and Sexually Transmitted Infections, Brasília, Brazil (S.P. Giozza, G.F. Pereira); National Reference Center for Tropical Infectious Diseases, Hamburg, Germany (G.L. Wallau)

Main Article

Figure 5

Maximum-likelihood phylogenetic tree supporting Zika virus reinfection among study participants in northern Brazil. The tree shows the 5 participants with divergent samples in which coinfection by different ZIKV genomes was inferred by phylogenetic reconstruction. Divergent samples from the same participant were grouped separately in the tree. Boldface indicates participant identification numbers; visit numbers (V) are indicated. Scale bar indicates number of nucleotide substitutions per site. Numbers on the branches indicate Shimodaira–Hasegawa approximate likelihood ratio test after 1,000 replicates.

Figure 5. Maximum-likelihood phylogenetic tree supporting Zika virus reinfection among study participants in northern Brazil. The tree shows the 5 participants with divergent samples in which coinfection by different ZIKV genomes was inferred by phylogenetic reconstruction. Divergent samples from the same participant were grouped separately in the tree. Boldface indicates participant identification numbers; visit numbers (V) are indicated. Scale bar indicates number of nucleotide substitutions per site. Numbers on the branches indicate Shimodaira–Hasegawa approximate likelihood ratio test after 1,000 replicates.

Main Article

1These authors contributed equally to this article.

Page created: January 09, 2024
Page updated: January 24, 2024
Page reviewed: January 24, 2024
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