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Volume 30, Number 4—April 2024
Research

Clostridium butyricum Bacteremia Associated with Probiotic Use, Japan

Ryuichi Minoda SadaComments to Author , Hiroo Matsuo, Daisuke Motooka, Satoshi Kutsuna, Shigeto Hamaguchi, Go Yamamoto, and Akiko Ueda
Author affiliations: Osaka University Graduate School of Medicine, Osaka, Japan (R.M. Sada, H. Matsuo, S. Kutsuna, S. Hamaguchi, G. Yamamoto); Osaka University Research Institute for Microbial Diseases, Osaka (D. Motooka); Osaka University Hospital, Suita, Osaka (A. Ueda)

Main Article

Figure

Phylogenetic tree reflecting the relationship between Clostridium butyricum MIYAIRI 588, clinical isolates of C. butyricum, and 8 reference strains based on data from a single-institute, retrospective study, Osaka University Hospital, Japan. Note: 114-4, 129-32, 180-11, 181-16, and 216-41 represent strain numbers of clinical isolates of C. butyricum. MIYAIRI 588 indicates C. butyricum MIYAIRI 588. DSM10702 (GCA_014131795.1), NBRC 13949 (GCA_006742065.1), DSM 10702 (GCA_000409755.1), NBRC 13949 (GCA_007992895.1), NBRC 3315 (GCA_007992895.1), ATCC 43755 (GCA_011017415.1), CDC 51208 (GCA_001886875.1), and NBRC 3858 (GCA_007992875.1) represent 8 reference strains. ANI was calculated using FastANI (31). ANI, average nucleotide identity.

Figure. Phylogenetic tree reflecting the relationship between Clostridium butyricum MIYAIRI 588, clinical isolates of C. butyricum, and 8 reference strains based on data from a single-institute, retrospective study, Osaka University Hospital, Japan. Note: 114-4, 129-32, 180-11, 181-16, and 216-41 represent strain numbers of clinical isolates of C. butyricum. MIYAIRI 588 indicates C. butyricum MIYAIRI 588. DSM10702 (GCA_014131795.1), NBRC 13949 (GCA_006742065.1), DSM 10702 (GCA_000409755.1), NBRC 13949 (GCA_007992895.1), NBRC 3315 (GCA_007992895.1), ATCC 43755 (GCA_011017415.1), CDC 51208 (GCA_001886875.1), and NBRC 3858 (GCA_007992875.1) represent 8 reference strains. ANI was calculated using FastANI (31). ANI, average nucleotide identity.

Main Article

References
  1. Kerry  RG, Patra  JK, Gouda  S, Park  Y, Shin  HS, Das  G. Benefaction of probiotics for human health: A review. Yao Wu Shi Pin Fen Xi. 2018;26:927–39. DOIPubMedGoogle Scholar
  2. Collinson  S, Deans  A, Padua-Zamora  A, Gregorio  GV, Li  C, Dans  LF, et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev. 2020;12:CD003048.PubMedGoogle Scholar
  3. Zhang  T, Zhang  C, Zhang  J, Sun  F, Duan  L. Efficacy of probiotics for irritable bowel syndrome: a systematic review and network meta-analysis. Front Cell Infect Microbiol. 2022;12:859967. DOIPubMedGoogle Scholar
  4. Hempel  S, Newberry  SJ, Maher  AR, Wang  Z, Miles  JN, Shanman  R, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA. 2012;307:1959–69. DOIPubMedGoogle Scholar
  5. Zhu  J, Pitre  T, Ching  C, Zeraatkar  D, Gruchy  S. Safety and efficacy of probiotic supplements as adjunctive therapies in patients with COVID-19: A systematic review and meta-analysis. PLoS One. 2023;18:e0278356. DOIPubMedGoogle Scholar
  6. Kerry  RG, Patra  JK, Gouda  S, Park  Y, Shin  HS, Das  G. Benefaction of probiotics for human health: A review. Yao Wu Shi Pin Fen Xi. 2018;26:927–39. DOIPubMedGoogle Scholar
  7. Mountzouris  KC, McCartney  AL, Gibson  GR. Intestinal microflora of human infants and current trends for its nutritional modulation. Br J Nutr. 2002;87:405–20. DOIPubMedGoogle Scholar
  8. Tran  NT, Li  Z, Ma  H, Zhang  Y, Zheng  H, Gong  Y, et al. Clostridium butyricum: a promising probiotic confers positive health benefits in aquatic animals. Rev Aquacult. 2020;12:2573–89. DOIGoogle Scholar
  9. Finegold  SM, Sutter  VL, Mathisen  GE. Normal indigenous intestinal flora. In: Hentges DJ, editor. Human Intestinal Microflora in Health and Disease. New York: Elsevier Inc. 1983. p. 1:3–31.
  10. Ghoddusi  HB, Sherburn  R. Preliminary study on the isolation of Clostridium butyricum strains from natural sources in the UK and screening the isolates for presence of the type E botulinal toxin gene. Int J Food Microbiol. 2010;142:202–6. DOIPubMedGoogle Scholar
  11. Isa  K, Oka  K, Beauchamp  N, Sato  M, Wada  K, Ohtani  K, et al. Safety assessment of the Clostridium butyricum MIYAIRI 588® probiotic strain including evaluation of antimicrobial sensitivity and presence of Clostridium toxin genes in vitro and teratogenicity in vivo. Hum Exp Toxicol. 2016;35:818–32. DOIPubMedGoogle Scholar
  12. Maeda  A, Ishii  K, Tanaka  M, Mikami  Y, Arai  T. KM1, a bacteriophage of Clostridium butyricum. Microbiology. 1986;132:2271–5. DOIGoogle Scholar
  13. Oka  K, McCartney  E, Ariyoshi  T, Kudo  H, Vilá  B, de Jong  L, et al. In vivo safety evaluation of the Clostridium butyricum MIYAIRI 588 strain in broilers, piglets, and turkeys. Toxicol Res Appl. 2019;3. DOIGoogle Scholar
  14. Hagihara  M, Ariyoshi  T, Kuroki  Y, Eguchi  S, Higashi  S, Mori  T, et al. Clostridium butyricum enhances colonization resistance against Clostridioides difficile by metabolic and immune modulation. Sci Rep. 2021;11:15007. DOIPubMedGoogle Scholar
  15. Takahashi  M, Taguchi  H, Yamaguchi  H, Osaki  T, Sakazaki  R, Kamiya  S. [Antagonistic interaction between Clostridium butyricum and enterohemorrhagic Escherichia coli O157:H7] [in Japanese]. Kansenshogaku Zasshi. 1999;73:7–14. DOIPubMedGoogle Scholar
  16. Seki  H, Shiohara  M, Matsumura  T, Miyagawa  N, Tanaka  M, Komiyama  A, et al. Prevention of antibiotic-associated diarrhea in children by Clostridium butyricum MIYAIRI. Pediatr Int. 2003;45:86–90. DOIPubMedGoogle Scholar
  17. Muldrew  KL. Rapidly fatal postlaparoscopic liver infection from the rarely isolated species Clostridium butyricum. Case Rep Infect Dis. 2020;2020:1839456. DOIPubMedGoogle Scholar
  18. Smith  MF, Borriello  SP, Clayden  GS, Casewell  MW. Clinical and bacteriological findings in necrotising enterocolitis: a controlled study. J Infect. 1980;2:23–31. DOIPubMedGoogle Scholar
  19. Sato  Y, Kujirai  D, Emoto  K, Yagami  T, Yamada  T, Izumi  M, et al. Necrotizing enterocolitis associated with Clostridium butyricum in a Japanese man. Acute Med Surg. 2018;5:194–8. DOIPubMedGoogle Scholar
  20. Cassir  N, Benamar  S, La Scola  B. Clostridium butyricum: from beneficial to a new emerging pathogen. Clin Microbiol Infect. 2016;22:37–45. DOIPubMedGoogle Scholar
  21. Cassir  N, Benamar  S, Khalil  JB, Croce  O, Saint-Faust  M, Jacquot  A, et al. Clostridium butyricum strains and dysbiosis linked to necrotizing enterocolitis in preterm neonates. Clin Infect Dis. 2015;61:1107–15. DOIPubMedGoogle Scholar
  22. Shimura  M, Mizuma  M, Nakagawa  K, Aoki  S, Miura  T, Takadate  T, et al. Probiotic-related bacteremia after major hepatectomy for biliary cancer: a report of two cases. Surg Case Rep. 2021;7:133. DOIPubMedGoogle Scholar
  23. Ishikawa  K, Hasegawa  R, Shibutani  K, Mikami  Y, Kawai  F, Matsuo  T, et al. Probiotic-related Clostridium butyricum bacteremia: a case report and literature review. Anaerobe. 2023;83:102770. DOIPubMedGoogle Scholar
  24. von Elm  E, Altman  DG, Egger  M, Pocock  SJ, Gøtzsche  PC, Vandenbroucke  JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. 2007;147:573–7. DOIPubMedGoogle Scholar
  25. Sulaiman  IM, Miranda  N, Simpson  S. MALDI-TOF mass spectrometry and 16S rRNA gene sequence analysis for the identification of foodborne Clostridium spp. J AOAC Int. 2021;104:1381–8. DOIPubMedGoogle Scholar
  26. Quan  H, Li  B, Couris  CM, Fushimi  K, Graham  P, Hider  P, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173:676–82. DOIPubMedGoogle Scholar
  27. Wilkins  T, Sequoia  J. Probiotics for gastrointestinal conditions: a summary of the evidence. Am Fam Physician. 2017;96:170–8.PubMedGoogle Scholar
  28. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing, 33rd ed (M100-ED33). Wayne (PA): The Institute; 2023.
  29. Mory  F, Lozniewski  A, Bland  S, Sedallian  A, Grollier  G, Girard-Pipau  F, et al. Survey of anaerobic susceptibility patterns: a French multicentre study. Int J Antimicrob Agents. 1998;10:229–36. DOIPubMedGoogle Scholar
  30. Hecht  DW. Anaerobes: antibiotic resistance, clinical significance, and the role of susceptibility testing. Anaerobe. 2006;12:115–21. DOIPubMedGoogle Scholar
  31. Jain  C, Rodriguez-R  LM, Phillippy  AM, Konstantinidis  KT, Aluru  S. High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries. Nat Commun. 2018;9:5114. DOIPubMedGoogle Scholar
  32. McKenna  A, Hanna  M, Banks  E, Sivachenko  A, Cibulskis  K, Kernytsky  A, et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 2010;20:1297–303. DOIPubMedGoogle Scholar
  33. Cingolani  P, Platts  A, Wang  L, Coon  M, Nguyen  T, Wang  L, et al. A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin). 2012;6:80–92. DOIPubMedGoogle Scholar
  34. Tanizawa  Y, Fujisawa  T, Nakamura  Y. DFAST: a flexible prokaryotic genome annotation pipeline for faster genome publication. Bioinformatics. 2018;34:1037–9. DOIPubMedGoogle Scholar
  35. Meier-Kolthoff  JP, Göker  M. TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy. Nat Commun. 2019;10:2182. DOIPubMedGoogle Scholar
  36. Costa  RL, Moreira  J, Lorenzo  A, Lamas  CC. Infectious complications following probiotic ingestion: a potentially underestimated problem? A systematic review of reports and case series. BMC Complement Altern Med. 2018;18:329. DOIPubMedGoogle Scholar
  37. Linz  B, Windsor  HM, McGraw  JJ, Hansen  LM, Gajewski  JP, Tomsho  LP, et al. A mutation burst during the acute phase of Helicobacter pylori infection in humans and rhesus macaques. Nat Commun. 2014;5:4165. DOIPubMedGoogle Scholar
  38. Hassoun-Kheir  N, Snitser  O, Hussein  K, Rabino  G, Eluk  O, Warman  S, et al. Concordance between epidemiological evaluation of probability of transmission and whole genome sequence relatedness among hospitalized patients acquiring Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2021;27:468.e1–7. DOIPubMedGoogle Scholar
  39. Goldenberg  JZ, Lytvyn  L, Steurich  J, Parkin  P, Mahant  S, Johnston  BC. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015;12:CD004827. DOIPubMedGoogle Scholar
  40. Goldenberg  JZ, Ma  SS, Saxton  JD, Martzen  MR, Vandvik  PO, Thorlund  K, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2013;5:CD006095. DOIGoogle Scholar
  41. Xu  J, Ma  R, Chen  LF, Zhao  LJ, Chen  K, Zhang  RB. Effects of probiotic therapy on hepatic encephalopathy in patients with liver cirrhosis: an updated meta-analysis of six randomized controlled trials. Hepatobiliary Pancreat Dis Int. 2014;13:354–60. DOIPubMedGoogle Scholar
  42. Naidoo  K, Gordon  M, Fagbemi  AO, Thomas  AG, Akobeng  AK. Probiotics for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2011;12:CD007443. DOIPubMedGoogle Scholar

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