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Volume 30, Number 4—April 2024
Research

Clostridium butyricum Bacteremia Associated with Probiotic Use, Japan

Ryuichi Minoda SadaComments to Author , Hiroo Matsuo, Daisuke Motooka, Satoshi Kutsuna, Shigeto Hamaguchi, Go Yamamoto, and Akiko Ueda
Author affiliations: Osaka University Graduate School of Medicine, Osaka, Japan (R.M. Sada, H. Matsuo, S. Kutsuna, S. Hamaguchi, G. Yamamoto); Osaka University Research Institute for Microbial Diseases, Osaka (D. Motooka); Osaka University Hospital, Suita, Osaka (A. Ueda)

Main Article

Table 2

Antimicrobial drug susceptibility of clinical bacterial strains from 5 patients who tested positive for Clostridium butyricum in a single-institute, retrospective study, Osaka University Hospital, Japan, and 3 medicinal strains from different lot numbers of C. butyricum MIYAIRI 588 strain

Category
Patient strains

Medicinal strains of CBM 588
Patient no. 1 2 3 4 5
Strain no.
114–4
129–32
180–11
181–16
216–41

No. 1
No. 2
No. 3
Antimicrobial drug
Penicillin 0.25 0.25 0.5 0.5 0.25 0.25 0.25 0.25
Ampicillin 0.25 0.25 0.25 0.25 0.25 0.12 0.25 0.25
Cefotaxime 32 32 32 32 32 32 32 32
Ceftriaxone 8 8 16 8 16 8 16 8
Cefmetazole ≤4 ≤4 8 ≤4 ≤4 ≤4 ≤4 ≤4
Imipenem 1 1 2 1 1 1 1 1
Meropenem ≤0.12 ≤0.12 0.5 ≤0.12 ≤0.12 ≤0.12 ≤0.12 ≤0.12
Sulbactam/ampicillin ≤2 ≤2 ≤2 ≤2 ≤2 ≤2 ≤2 ≤2
Clavulanic acid/amoxicillin 0.25 0.25 0.5 0.25 0.25 0.12 0.25 0.12
Tazobactam/piperacillin ≤8 ≤8 ≤8 ≤8 ≤8 ≤8 ≤8 ≤8
Clindamycin 0.5 0.25 0.5 0.5 0.25 0.25 0.5 0.25
Moxifloxacin ≤0.5 ≤0.5 ≤0.5 ≤0.5 ≤0.5 ≤0.5 ≤0.5 ≤0.5
Metronidazole ≤2 ≤2 ≤2 ≤2 ≤2 ≤2 ≤2 ≤2

Main Article

Page created: February 06, 2024
Page updated: March 20, 2024
Page reviewed: March 20, 2024
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