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Volume 30, Number 6—June 2024
Research

SARS-CoV-2 Disease Severity and Cycle Threshold Values in Children Infected during Pre-Delta, Delta, and Omicron Periods, Colorado, USA, 2021–2022

Laura BankersComments to Author , Shannon C. O’Brien, Diana M. Tapay, Erin Ho, Isaac Armistead, Alexis Burakoff, Samuel R. Dominguez, and Shannon R. Matzinger
Author affiliations: Colorado Department of Public Health and Environment, Denver, Colorado, USA (L. Bankers, S.C. O’Brien, D.M. Tapay, I. Armistead, A. Burakoff, S.R. Matzinger); University of Colorado, Aurora, Colorado, USA (E. Ho, S.R. Dominguez); Children’s Hospital Colorado, Aurora (E. Ho, S.R. Dominguez)

Main Article

Figure 4

Ct value patterns among markers of disease severity across variant periods in study of SARS-CoV-2 disease severity in children during pre-Delta, Delta, and Omicron periods, Colorado, USA, January 2021–January 2022. Boxplots indicate overall Ct value patterns across disease severity markers by variant period. A) Patient type (outpatient/not hospitalized, hospitalized because of COVID-19); B) symptomatic versus asymptomatic; C) number of days between symptom onset and positive test (symptom onset groups); D) hospitalized but not admitted to PICU versus admitted to PICU; E) any type of supplemental oxygen support versus no oxygen support received; F) highest level of supplemental oxygen support received (none, noninvasive oxygen support, invasive oxygen support). Red = pre-Delta, Blue = Delta, Orange = Omicron. Significance was determined using 2-way analysis of variance with Tukey test. Brackets indicate which comparisons correspond to the significance codes, and connected brackets indicate comparisons that have the same significance code. Ct, cycle threshold; PICU, pediatric intensive care unit.

Figure 4. Ct value patterns among markers of disease severity across variant periods in study of SARS-CoV-2 disease severity in children during pre-Delta, Delta, and Omicron periods, Colorado, USA, January 2021–January 2022. Boxplots indicate overall Ct value patterns across disease severity markers by variant period. A) Patient type (outpatient/not hospitalized, hospitalized because of COVID-19); B) symptomatic versus asymptomatic; C) number of days between symptom onset and positive test (symptom onset groups); D) hospitalized but not admitted to PICU versus admitted to PICU; E) any type of supplemental oxygen support versus no oxygen support received; F) highest level of supplemental oxygen support received (none, noninvasive oxygen support, invasive oxygen support). Red = pre-Delta, Blue = Delta, Orange = Omicron. Significance was determined using 2-way analysis of variance with Tukey test. Brackets indicate which comparisons correspond to the significance codes, and connected brackets indicate comparisons that have the same significance code. Ct, cycle threshold; PICU, pediatric intensive care unit.

Main Article

Page created: April 08, 2024
Page updated: May 22, 2024
Page reviewed: May 22, 2024
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