Volume 30, Number 6—June 2024
Research
SARS-CoV-2 Disease Severity and Cycle Threshold Values in Children Infected during Pre-Delta, Delta, and Omicron Periods, Colorado, USA, 2021–2022
Laura Bankers
, Shannon C. O’Brien, Diana M. Tapay, Erin Ho, Isaac Armistead, Alexis Burakoff, Samuel R. Dominguez, and Shannon R. Matzinger
, Shannon C. O’Brien, Diana M. Tapay, Erin Ho, Isaac Armistead, Alexis Burakoff, Samuel R. Dominguez, and Shannon R. Matzinger
Table 3
Mean nucleocapsid gene cycle threshold values by category in study of SARS-CoV-2 disease severity in children during pre-Delta, Delta, and Omicron periods, Colorado, USA, January 2021–January 2022*
| Characteristic |
Cycle threshold (+SD) |
|||
|---|---|---|---|---|
| All |
Pre-Delta period |
Delta period |
Omicron period |
|
| All | 22.4 (6.79) | 26.5 (6.96) | 22.8 (7.81) | 22.9 (5.51) |
| Age group, y | ||||
| <1 | 19.5 (6.54) | 22.0 (7.49) | 17.2 (6.64) | 21.4 (5.79) |
| 1–4 | 22.6 (6.74) | 24.7 (6.53) | 21.4 (7.61) | 21.9 (4.82) |
| 5–11 | 23.2 (6.61) | 23.1 (7.07) | 23.1 (6.85) | 23.0 (5.44) |
| >12 |
23.3 (6.73) |
24.1 (7.28) |
22.2 (6.77) |
24.7 (5.39) |
| Time from symptom onset, d | ||||
| 0–3 | 20.7 (6.32) | 21.5 (6.36) | 20.5 (6.95) | 20.4 (4.71) |
| 4–7 | 21.9 (5.85) | 20.1 (5.02) | 22.1 (6.49) | 22.3 (4.47) |
| 8–14 |
25.8 (5.58) |
29.0 (6.22) |
24.7 (5.79) |
26.7 (3.48) |
| Vaccination status | ||||
| Unvaccinated | 22.2 (6.53) | 23.6 (7.17) | 21.2 (7.31) | 22.2 (5.53) |
| Vaccinated (any doses) | 23.2 (6.76) | 24.1 (6.99) | 22.9 (6.87) | 22.8 (4.67) |
| Partially vaccinated (1 dose) | 23.4 (7.45) | 28.5 (7.33) | 21.0 (6.43) | 23.7 (5.16) |
| Fully vaccinated (2 doses) | 23.0 (6.59) | 22.5 (6.51) | 23.0 (6.91) | 22.8 (4.80) |
| Fully vaccinated + booster |
25.3 (6.81) |
25.9 (6.92) |
24.5 (7.26) |
20.7 (3.04) |
| Disease severity | ||||
| Outpatient | 22.1 (6.47) | 22.4 (6.79) | 21.4 (7.07) | 21.9 (5.40) |
| Inpatient, hospitalized with COVID-19 | 26.2 (6.92) | 27.9 (6.93) | 24.3 (8.25) | 25.5 (5.70) |
| Inpatient, hospitalized because of COVID-19 | 22.1 (6.31) | 24.6 (6.62) | 22.1 (7.53) | 21.3 (4.75) |
| Symptomatic | 21.5 (6.37) | 21.6 (6.24) | 21.7 (7.02) | 21.4 (5.24) |
| Asymptomatic | 22.5 (6.80) | 23.7 (6.99) | 21.6 (7.29) | 22.4 (5.43) |
| Admitted to PICU because of COVID-19 | 21.9 (5.84) | 22.5 (5.95) | 22.3 (6.88) | 21.0 (4.17) |
| Hospitalized but not admitted to PICU | 22.1 (6.50) | 25.3 (6.76) | 21.9 (8.04) | 21.3 (4.97) |
| No supplemental oxygen | 24.3 (7.16) | 27.8 (7.62) | 22.3 (8.35) | 23.5 (5.12) |
| Any supplemental oxygen | 21.3 (5.82) | 22.1 (6.55) | 22.1 (6.60) | 20.7 (4.79) |
| Noninvasive supplemental oxygen | 21.4 (5.67) | 22.2 (5.59) | 22.7 (6.66) | 20.4 (4.72) |
| Invasive supplemental oxygen | 20.9 (6.82) | 22.0 (10.2) | 18.7 (5.40) | 22.7 (5.35) |
*PICU, pediatric intensive care unit.
Page created: April 08, 2024
Page updated: May 22, 2024
Page reviewed: May 22, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.