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Volume 30, Number 6—June 2024
Research Letter
Novel Avian Influenza A(H5N6) in Wild Birds, South Korea, 2023
Andrew Yong Cho1, Young-Jae Si1, Dong-Ju Kim1, Ye-Ram Seo, Dong-Yeop Lee, Daehun Kim, Dongbin Lee, Yaemoon Son, Hyesung Jeong, Chang-Seon Song, and Dong-Hun Lee
Table
Nucleotide sequence identities between gene segments of novel clade 2.3.4.4b highly pathogenic avian influenza A(H5N6) virus isolate A/Whooper_Swan/Korea/23WC075/2023 from South Korea and nearest top 3 homologs in the GISAID EpiFlu database*
| Gene | Top 3 query | Accession no. | Nucleotide identity | % Identity |
|---|---|---|---|---|
| PB2 |
A/peregrine falcon/Saga/4112A002/2023 (A/H5N6) segment 1 (PB2) | EPI2898974 | 2280/2280 | 100.00 |
| A/environment/chongqing/1795/2023 (A/H9N2) segment 1 (PB2) | EPI2841012 | 2271/2280 | 99.61 | |
| A/environment/Kagoshima/KU-I6/2021 (H4N6) (A/H4N6) segment 1 (PB2) |
EPI2553141 |
2253/2280 |
98.82 |
|
| PB1 |
A/peregrine falcon/Saga/4112A002/2023 (A/H5N6) segment 2 (PB1) | EPI2898975 | 2273/2274 | 99.96 |
| A/egret/Korea/22WC394/2023 (A/H5N1) segment 2 (PB1) | EPI2743089 | 2271/2274 | 99.87 | |
| A/common buzzard/Korea/22WC336/2023 (A/H5N1) segment 2 (PB1) |
EPI2742993 |
2271/2274 |
99.87 |
|
| PA |
A/peregrine falcon/Saga/4112A002/2023 (A/H5N6) segment 3 (PA) | EPI2898976 | 2150/2151 | 99.95 |
| A/common teal/Amur region/92b/2020 (A/H6N2) segment 3 (PA) | EPI1849993 | 2142/2151 | 99.58 | |
| A/mallard/Russia Primorje/94T/2020 (A/H1N1) segment 3 (PA) |
EPI1849961 |
2141/2151 |
99.54 |
|
| HA |
A/peregrine falcon/Saga/4112A002/2023 (A/H5N6) segment 4 (HA) | EPI2898977 | 1700/1704 | 99.77 |
| A/environment/Kagoshima/KU-G4/2022 (H5N1) (A/H5N1) segment 4 (HA) | EPI2789597 | 1697/1704 | 99.59 | |
| A/environment/Kagoshima/KU-D4/2022 (H5N1) (A/H5N1) segment 4 (HA) |
EPI2789589 |
1697/1704 |
99.59 |
|
| NP |
A/peregrine falcon/Saga/4112A002/2023 (A/H5N6) segment 5 (NP) | EPI2898978 | 1496/1497 | 99.93 |
| A/gadwall/Novosibirsk region/3407k/2020 (A/H4N6) segment 5 (NP) | EPI1849870 | 1479/1497 | 98.80 | |
| A/mallard/Novosibirsk region/3286k/2020 (A/H4N6) segment 5 (NP) |
EPI1849878 |
1478/1497 |
98.73 |
|
| NA |
A/peregrine falcon/Saga/4112A002/2023 (A/H5N6) segment 6 (NA) | EPI2898979 | 1377/1380 | 99.78 |
| A/duck/Hunan/S40199/2021(H5N6) (A/H5N6) segment 6 (NA) | EPI1997201 | 1360/1380 | 98.55 | |
| A/Changsha/1/2022 (A/H5N6) segment 6 (NA) |
EPI2287050 |
1359/1380 |
98.48 |
|
| M |
A/peregrine falcon/Saga/4112A002/2023 (A/H5N6) segment 7 (MP) | EPI2898980 | 982/982 | 100.00 |
| A/northern pintail/Kagoshima/KU-64/2022 (H5N1) (A/H5N1) segment 7 (MP) | EPI2794001 | 980/982 | 99.80 | |
| A/environment/Kagoshima/KU-B4/2022 (H5N1) (A/H5N1) segment 7 (MP) |
EPI2789385 |
980/982 |
99.80 |
|
| NS |
A/peregrine falcon/Saga/4112A002/2023 (A/H5N6) segment 8 (NS) | EPI2898981 | 837/838 | 99.88 |
| A/bean goose/Korea/KNU-10/2022 (A/H10N7) segment 8 (NS) | EPI2873490 | 836/838 | 99.76 | |
| A/bean goose/Korea/KNU-14/2022 (A/H6N1) segment 8 (NS) |
EPI2873460 |
836/838 |
99.76 |
|
| *GISAID, https://www.gisaid.org; HA, hemagglutinin; P, matrix; NA, neuraminidase; NP, nucleoprotein; NS, nonstructural; PA, polymerase acidic; PB, polymerase basic. | ||||
1These authors contributed equally to this article.
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