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Volume 30, Number 7—July 2024
Dispatch

Evidence of Orientia spp. Endemicity among Severe Infectious Disease Cohorts, Uganda

Paul W. BlairComments to Author , Kenneth Kobba, Stephen Okello, Sultanah Alharthi, Prossy Naluyima, Emily Clemens, Hannah Kibuuka, Danielle V. Clark, Francis Kakooza, Mohammed Lamorde, Yukari C. Manabe, J. Stephen Dumler, Acute Febrile Illness, and Sepsis in Uganda study teams1
Author affiliations: Uniformed Services University, Bethesda, Maryland, USA (P.W. Blair, S. Alharthi, E. Clemens, J.S. Dumler); Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda (P.W. Blair, S. Alharthi, D.V. Clark); Johns Hopkins University School of Medicine, Baltimore, Maryland, USA (P.W. Blair, Y.C. Manabe); Infectious Diseases Institute, Makerere University, Kampala, Uganda (K. Kobba, F. Kakooza, M. Lamorde); Makerere University Walter Reed Project, Kampala (S. Okello, P. Naluyima, H. Kibuuka)

Main Article

Table 2

Clinical characteristics of participants with Orientia spp. seroconversion in a study of Orientia genus endemicity among severe infectious disease cohorts, Uganda*

Characteristics Patient identification
A B C D
Age, y/sex 24/M 34/F 23/F 56/F
Occupation Mine worker Business or trade Fuel attendant Farmer
Rash, type
 Y, pustular and eschar
 Y, papular
 N
 N
Clinical laboratory parameters
WBC, x 103 cells/μL 7 10 5 8
Platelet count, x 103 cells/μL 56 220 128 177
AST, U/L
 21
 62
 136
 26
Microbiologic results†
HIV (CD4) + (603) + (NA) + (NA) ­–
Malaria smear +, 126 parasites/μL – – –
TB
PCR NA NA NA –
Urine LAM
 +
 –
 –
 NA
Clinical diagnosis TB Urinary tract infection Unidentified Abdominal source
Inpatient treatment ACT CIP, CTX, MTZ CTX, cefixime CIP, MTZ
Outcome
 Survived
 Died, 8.2 mo.
 Survived
 Survived
*ACT, artemisinin-based combination therapy; AST, aspartate transaminase; CIP, ciprofloxacin; CTX, ceftriaxone; LAM, lipoarabinomman; MTZ, metronidazole; NA, not available; NG, no growth; TB, tuberculosis; WBC, white blood cells; –, negative; +, positive.
†All had negative blood cultures and negative multiplex PCR results.

Main Article

1Members of the Acute Febrile Illness and Sepsis in Uganda study teams are listed at the end of this article.

Page created: May 10, 2024
Page updated: June 22, 2024
Page reviewed: June 22, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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