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Volume 30, Number 8—August 2024
Research

Potential of Pan-Tuberculosis Treatment to Drive Emergence of Novel Resistance

C. Finn McQuaidComments to Author , Theresa S. Ryckman, Nicolas A. Menzies, Richard G. White, Ted Cohen, and Emily A. Kendall
Author affiliations: London School of Hygiene and Tropical Medicine, London, UK (C.F. McQuaid, R.G. White); Johns Hopkins University School of Medicine, Baltimore, Maryland, USA (T.S. Ryckman, E.A. Kendall); Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA (N.A. Menzies); Yale School of Public Health, New Haven, Connecticut, USA (T. Cohen)

Main Article

Figure 5

Prevalence of complex resistance to both R and a pan-TB treatment regimen component (B, X, or both) resulting from the pan-TB compared with standard-of-care scenario in study of potential of pan-TB treatment to drive emergence of novel resistance. A) Prevalence over treatment generations; B) probability that the pan-TB scenario leads to higher prevalence of complex resistance as a proportion of all TB after 10 cohorts. Red indicates when pan-TB regimen performs better (<50% probability of higher prevalence of complex resistance) and blue when SoC regimen performs better. B, diarylquinolines; SoC, standard of care; TB, tuberculosis.

Figure 5. Prevalence of complex resistance to both R and a pan-TB treatment regimen component (B, X, or both) resulting from the pan-TB compared with standard-of-care scenario in study of potential of pan-TB treatment to drive emergence of novel resistance. A) Prevalence over treatment generations; B) probability that the pan-TB scenario leads to higher prevalence of complex resistance as a proportion of all TB after 10 cohorts. Red indicates when pan-TB regimen performs better (<50% probability of higher prevalence of complex resistance) and blue when SoC regimen performs better. B, diarylquinolines; SoC, standard of care; TB, tuberculosis.

Main Article

Page created: June 21, 2024
Page updated: July 20, 2024
Page reviewed: July 20, 2024
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