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Volume 30, Number 8—August 2024
Research

Detection of Nucleocapsid Antibodies Associated with Primary SARS-CoV-2 Infection in Unvaccinated and Vaccinated Blood Donors

Eduard Grebe1Comments to Author , Mars Stone1, Bryan R. Spencer, Akintunde Akinseye, David Wright, Clara Di Germanio, Roberta Bruhn, Karla G. Zurita, Paul Contestable, Valerie Green, Marion C. Lanteri, Paula Saa, Brad J. Biggerstaff, Melissa M. Coughlin, Steve Kleinman, Brian Custer, Jefferson M. Jones, and Michael P. Busch
Author affiliations: Vitalant Research Institute, San Francisco, California, USA (E. Grebe, M. Stone, C. Di Germanio, R. Bruhn, K.G. Zurita, B. Custer, M.P. Busch); University of California, San Francisco (M. Stone, R. Bruhn, M.C. Lanteri, B. Custer, M.P. Busch); American Red Cross, Rockville, Maryland, USA (B.R. Spencer, P. Saa); Westat, Rockville (A. Akinseye, D. Wright); QuidelOrtho, Rochester, New York, USA (P. Contestable); Creative Testing Solutions, Tempe, Arizona, USA (V. Green, M.C. Lanteri); Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (B.J. Biggerstaff); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.M. Coughlin, J.M. Jones); University of British Columbia, Vancouver, British Columbia, Canada (S. Kleinman)

Main Article

Figure 3

Sensitivity of nucleocapsid antibody serologic tests by time from swab-confirmed infection to sample collection in vaccinated and unvaccinated blood donors, using the manufacturer’s recommended cutoff, United States, July 2021–December 2022. The percentage of donors showing reactivity in first or subsequent samples after swab-confirmed infection is shown. A) Reactive proportions stratified by vaccination status at the time of infection. B) Infections in unvaccinated donors stratified by reported symptoms. C) Reactive proportions in unvaccinated donors with swab-confirmed infections stratified by reported symptoms. To account for multiple observations per time bin, observations were weighted so that donors were equally weighted within each time bin, regardless of the number of observations. Error bars indicate median and maximum durations of follow-up for each group.

Figure 3. Sensitivity of nucleocapsid antibody serologic tests by time from swab-confirmed infection to sample collection in vaccinated and unvaccinated blood donors, using the manufacturer’s recommended cutoff, United States, July 2021–December 2022. The percentage of donors showing reactivity in first or subsequent samples after swab-confirmed infection is shown. A) Reactive proportions stratified by vaccination status at the time of infection. B) Infections in unvaccinated donors stratified by reported symptoms. C) Reactive proportions in unvaccinated donors with swab-confirmed infections stratified by reported symptoms. To account for multiple observations per time bin, observations were weighted so that donors were equally weighted within each time bin, regardless of the number of observations. Error bars indicate median and maximum durations of follow-up for each group.

Main Article

1These first authors contributed equally to this article.

Page created: June 10, 2024
Page updated: July 09, 2024
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