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Volume 30, Number 9—September 2024
Dispatch

Emergence of Extensively Drug-Resistant Neisseria gonorrhoeae, France, 2023

François Caméléna, Manel Mérimèche, Julie Brousseau, Mary Mainardis, Pascale Verger, Caroll Le Risbé, Elise Brottet, Alexandra Thabuis, Cécile Bébéar, Jean-Michel Molina, Florence Lot, Emilie Chazelle1, and Béatrice Berçot1Comments to Author 
Author affiliations: Saint Louis–Lariboisière University Hospitals, Paris, France (F. Caméléna, M. Mérimèche, J. Brousseau, M. Mainardis, J.-M. Molina, B. Berçot); French National Reference Center for bacterial STI, Paris (F. Caméléna, M. Mérimèche, J. Brousseau, M. Mainardis, B. Berçot); Paris Cité University, Paris (F. Caméléna, M. Mérimèche, J. Brousseau, J.-M. Molina, B. Berçot); Biogroup Oriade Noviale, Saint Martin d'Hères, France (P. Verger, C. Le Risbé); National Public Health Agency, Lyon, France (E. Brottet, A. Thabuis); National Reference Centre for Bacterial Sexually Transmitted Infections, Bordeaux, France (C. Bébéar); University Bordeaux, Bordeaux (C. Bébéar); Santé publique France, Saint-Maurice, France (F. Lot, E. Chazelle).

Main Article

Table

MICs and molecular resistance mechanisms of extremely drug-resistant Neisseria gonorrhoeae strains F95 and F96, recovered from 2 patients in France, 2023*

Antimicrobial F95 MIC, mg/L F96 MIC, mg/L EUCAST interpretation Molecular mechanism(s) of resistance
Penicillin
 >32
 >32
 R
 blaTEM-135
Cefixime 1 1 R penA 60.001 (mosaic; A311V; T483S); mtrR, A39T; ponA, L421P; porB structure, porB1a
Ceftriaxone 0.25 0.25 R
Cefotaxime
 0.5
 0.5
 R
Ertapenem
 0.032
 0.016
 NA
 NA
Azithromycin
 >256
 >256
 R (high-level)
 23S rRNA, A2059G; mtrR, A39T
Tetracycline 32 32 R (high-level) tetM; rpsJ, V57M; mtrR, A39T
Doxycycline
 16
 16
 R
Ciprofloxacin
 2
 4
 R
 gyrA, S91F and D95A; parC, S87R
Spectinomycin
 16
 16
 S
 NA
Gentamicin
 8
 8
 NA
 NA
Rifampin
 0.125
 0.064
 NA
 NA
*MIC testing done using ETEST (bioMérieux, https://www.biomerieux.com). EUCAST, European Committee on Antimicrobial Susceptibility testing; NA, not applicable because of a lack of breakpoints for interpretation; R, resistant; S, susceptible.

Main Article

1These authors contributed equally to this article.

Page created: July 12, 2024
Page updated: July 31, 2024
Page reviewed: July 31, 2024
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