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Volume 31, Number 1—January 2025
Research Letter
Spread of Antifungal-Resistant Trichophyton indotineae, United Kingdom, 2017–2024
Alireza Abdolrasouli, Richard C. Barton, and Andrew M. Borman
Table
Characteristics of the 157 proven cases of in an investigation of spread of antifungal-resistant T. indotineae infection, United Kingdom, 2017–2024*
| Characteristics | No. (%), n = 157 |
|---|---|
| Patient age range, y | |
| 1–10 | 4 (2.5) |
| 11–20 | 13 (8.3) |
| 21–30 | 37 (23.6) |
| 31–40 | 42 (26.8) |
| 41–50 | 26 (16.6) |
| 51–60 | 18 (11.5) |
| 61–70 | 13 (8.3) |
| 71–80 |
4 (2.5) |
| Anatomic site affected† | |
| Buttock, groin, gluteal fold, perineum, thigh | 67 (42.7) |
| Back, abdomen, torso, trunk, breast, chest | 18 (11.5) |
| Legs, feet, knee, toenail | 14 (8.9) |
| Arms, hands, axilla | 6 (3.8) |
| Face, neck, head | 6 (3.8) |
| Unknown |
53 (33.8) |
| Geographic location | |
| London | 73 (46.5) |
| England outside London | 54 (34.4) |
| Wales | 8 (5.1) |
| Scotland | 19 (12.1) |
| Republic of Ireland |
3 (1.9) |
| Travel history‡ | |
| Yes | 41 (26.1) |
| No or unknown |
116 (73.9) |
| Patient links to endemic area | |
| Yes | 133 (84.7) |
| No | 12 (7.6) |
| Unknown |
12 (7.6) |
| Identification method | |
| Phenotypic only | 114 (72.6) |
| Molecular ITS or WGS |
43 (27.4) |
| Antifungal susceptibility testing | |
| Terbinafine, >0.5 mg/L | 92 (58.6) |
| Terbinafine, <0.5mg/L | 32 (20.4) |
| Terbinafine, not tested | 33 (21.0) |
| Itraconazole, >05 mg/L | 16 (10.2) |
| Itraconazole, <0.5 mg/L | 92 (58.6) |
| Itraconazole, not tested | 49 (31.2) |
*Detailed case listings and definitions are provided (Appendix Table). †Multiple sites reported in some cases; therefore, total >157 cases. ‡Travel to India, Bangladesh, Pakistan, Sri Lanka, UAE, Nepal.
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Page updated: December 17, 2024
Page reviewed: December 17, 2024
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