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Volume 31, Number 1—January 2025
Dispatch

Fatal Case of Crimean-Congo Hemorrhagic Fever, Portugal, 2024

Líbia Zé-Zé1Comments to Author , Cristina Nunes1, Micaela Sousa, Rita de Sousa, Carla Gomes, Ana S. Santos, Rui T. Alexandre, Fátima Amaro, Tiago Loza, Miriam Blanco, and Maria J. Alves
Author affiliation: National Institute of Health Doutor Ricardo Jorge, Águas de Moura, Portugal (L. Zé-Zé, R. de Sousa, A.S. Santos, F. Amaro, M.J. Alves); Center for the Study of Animal Science, Porto, Portugal (L. Zé-Zé, F. Amaro, M.J. Alves); Northeastern Local Health Unit, Bragança, Portugal (C. Nunes, M. Sousa, C. Gomes, R.T. Alexandre, T. Loza, M. Blanco); Environmental Health Institute, Lisboa, Portugal (A.S. Santos, F. Amaro, M.J. Alves)

Main Article

Table 1

Epidemiologic and clinical data for patient in a fatal case of Crimean-Congo hemorrhagic fever, Portugal, 2024*

Category
 Description
Patient information and event timeline
Risk factors
 Subsistence farmer; animal contact (chicken and donkey); living in a rural area
Comorbidity
 Hypertension, hypercholesterolemia, and prostate hypertrophy
Event
Epidemiologic exposure
 Patient reports tick removal on Jul 10
Symptoms onset
 Fever and myalgia, Jul 11
Presumptive diagnosis
 Mediterranean spotted fever, Jul 12
Signs and symptoms
 Fever, myalgia, nausea, vomit, and diarrhea, Jul 16
Petechiae, mild epistaxis, and gingival bleeding, Jul 18
Test results
Imaging, Jul 18
 Pleural effusion, lung widespread infiltrates, ascites, no hepatomegaly, or splenomegaly
Serum sample data, Jul 19
Real-time PCR
CCHFV commercial
 Ct 21.2
CCHFV in-house
 Ct 28.7
Rickettsia spp.
 Negative
Serology†
CCHFV-GPC IgM
 Negative (<16)
CCHFV-N IgM
 Pos itive(128)
CCHFV-GPC IgG
 Negative (<32)
CCHFV-N IgG
 Negative (<32)
SFGR IgM
 Negative (<32)
SFGR Rickettsia IgG Positive (128)

*CCHFV, Crimean-Congo hemorrhagic fever virus; Ct, cycle threshold; GPC, glycoprotein; N, nucleoprotein; SFGR, spotted fever group Rickettsia. †Cutoff values: CCHFV IgM>16, CCHFV IgG>32, Rickettsia IgM>32, Rickettsia IgG>128.

Main Article

1These first authors contributed equally to this article.

Page created: November 15, 2024
Page updated: December 22, 2024
Page reviewed: December 22, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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