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Volume 31, Number 10—October 2025

Research Letter

Jorge Lobo’s Disease in Child with Tick Exposure, Brazil

Franciely Gomes Gonçalves, Gabriel Zorello Laporta, Sebastião Afonso Viana Macedo Neves, Vânia Lúcia Queiroz de Barros, Rosineide Ferreira Bispo, Yally Alves da Silva Sbardelott, Pablo José Custódio Bezerra da Silva, Luiza Alves Vianna, Bernardo Guerra Tenório, João Paulo Romualdo Alarcão Bernardes, Florêncio Figueiredo Cavalcanti Neto, João Nóbrega de Almeida, and Marcus de Melo TeixeiraComments to Author 
Author affiliation: Centro Universitário Uninorte (UNINORTE), Rio Branco, Brazil (F.G. Gonçalves); Centro Universitário FMABC, Fundação ABC, Santo André, Brazil (F.G. Gonçalves, G.Z. Laporta); Serviço Estadual de Dermatologia do Acre, Rio Branco, Brazil (F.G. Gonçalves, V.L.Q. de Barros, R.F. Bispo, Y.A. da S. Sbardelott, P.J.C.B. Sliva); Núcleo de Medicina Tropical, Faculty of Medicine, University of Brasília, Campus Universitário Darcy Ribeiro, Brasília, Brazil (S.A.V.M. Neves, L.A. Vianna, B.G. Tenório, J.P.R.A. Bernardes, M. de Melo Teixeira); Faculdade de Saúde e Medicina, Universidade Católica de Brasília, Taguatinga-DF, Brazil (F.F.C. Neto); Antimicrobial Resistance Institute of São Paulo, São Paulo, Brazil (J. Nóbrega de Almeida Jr); Hospital Israelita Albert Einstein, São Paulo (J. Nóbrega de Almeida Jr, M. de Melo Teixeria)

Main Article

Figure 1

Nodule and histopathology in a case of Jorge Lobo’s disease in child with tick exposure, Brazil. A) Single granulomatous lesion on the right ear, which was surgically excised and histologically examined in 2018. B, C) Hematoxylin and eosin stain of nodule showing cells of the mononuclear phagocyte system, including monocytes, macrophages, epithelioid cells, and multinucleated giant cells, revealing granulomatous inflammation with spherical, double-walled yeast cells in branching chains (B) and prominent histiocytes and multinucleated giant cells (C), which are predominantly dense with areas of mild neovascularization, stromal hyalinization, and a slight infiltrate of lymphocytes and neutrophils. D) Grocott–Gomori methenamine silver stain of recurrent nodule from 2024 in which yeast-like fungal structures are diffusely distributed throughout the stroma and in the cytoplasm of phagocytic cells.

Figure 1. Nodule and histopathology in a case of Jorge Lobo’s disease in child with tick exposure, Brazil. A) Single granulomatous lesion on the right ear, which was surgically excised and histologically examined in 2018. B, C) Hematoxylin and eosin stain of nodule showing cells of the mononuclear phagocyte system, including monocytes, macrophages, epithelioid cells, and multinucleated giant cells, revealing granulomatous inflammation with spherical, double-walled yeast cells in branching chains (B) and prominent histiocytes and multinucleated giant cells (C), which are predominantly dense with areas of mild neovascularization, stromal hyalinization, and a slight infiltrate of lymphocytes and neutrophils. D) Grocott–Gomori methenamine silver stain of recurrent nodule from 2024 in which yeast-like fungal structures are diffusely distributed throughout the stroma and in the cytoplasm of phagocytic cells.

Main Article

Page created: August 27, 2025
Page updated: September 18, 2025
Page reviewed: September 18, 2025
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