Detection of Immunity Gap before Measles Outbreak, Ho Chi Minh City, Vietnam, 2024
Thinh Ong

, Cao Thu Thuy, Nguyen Hong Tam, Le Hong Nga, Nguyen Thi Vy Uyen, Truong Thi Thanh Lan, An Tran, Le Thi Kieu Diem, Huynh Phuc Khang, Dang Thi Xuan Dung, Lu Nhat Chuong, Nguyen Hoai Thao Tam, Vu Chau Giang, Tran Thi Bich Cam, Huynh Thi Ngoc Anh, Pham Thi Minh Thu, Dinh Nguyen Huy Man, Nguyen Thanh Dung, Nguyen Le Nhu Tung, Huynh Hong Phat, Le Mau Toan, Nguyen Thanh Lam, Pham Nguyen The Nguyen, Hoang Ngoc Nhung, Tran Tan Thanh, Nguyen Van Vinh Chau, Tang Chi Thuong, Guy Thwaites, C. Louise Thwaites, Marc Choisy, and Le Van Tan
Author affiliation: Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam (T. Ong, C.T. Thuy, N.T. Lam, P.N.T. Nguyen, H.N. Nhung, T.T. Thanh, G. Thwaites, C.L. Thwaites, M. Choisy, L.V. Tan); Ho Chi Minh City Center for Disease Control, Ho Chi Minh City (N.H. Tam, L.H. Nga, N.T.V. Uyen, T.T.T. Lan, A. Tran, L.T.K. Diem, H.P. Khang, D.T.X. Dung, L.N. Chuong, N.H.T. Tam, V.C. Giang, T.T.B. Cam, H.T.N. Anh, P.T.M. Thu); Hospital for Tropical Diseases, Ho Chi Minh City (D.N.H. Man, N.T. Dung, N.L.N. Tung, H.H. Phat, L.M. Toan); Department of Health, Ho Chi Minh City (N.V.V. Chau, T.C. Thuong); Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom (G. Thwaites, C.L. Thwaites, M. Choisy, L.V. Tan)
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Figure 1

Figure 1. Hospital locations, catchment areas, and number of cases per age in detection of immunity gap before a measles outbreak, Ho Chi Minh City, Vietnam, 2024. A) Children’s Hospital 1; B) Children’s Hospital 2; C) City Children’s Hospital. The first column shows seroprevalence as a function of time of collection for 2 age bands from each hospital; blue rectangles indicate the latest collections; dashed red lines represent the 95% critical vaccination threshold for measles; tick marks at top and bottom of graphs denote seropositive and negative samples; points represent monthly aggregated seroprevalence; error bars indicate 95% CI of the aggregated seroprevalence; shaded areas indicate 95% CI of the seroprevalence estimates by time of collection. Before the measles outbreak, the levels of seroprevalences were 70.7% (95% CI 57.6–81.1) for Children’s Hospital 1 in April 2024 (A), 58.1% (95% CI 44.1–70.9) for Children’s Hospital 2 in December 2023 (B), and 41.5% (95% CI 29.4–54.1) for City Children’s Hospital in December 2023 (C). The middle column shows age-stratified seroprevalence at the most recent timepoint (represented in blue rectangles from the first column). The third column maps the catchment areas based on sample addresses.
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