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Volume 31, Number 10—October 2025

Research Letter

Detection of Immunity Gap before Measles Outbreak, Ho Chi Minh City, Vietnam, 2024

Thinh OngComments to Author , Cao Thu Thuy, Nguyen Hong Tam, Le Hong Nga, Nguyen Thi Vy Uyen, Truong Thi Thanh Lan, An Tran, Le Thi Kieu Diem, Huynh Phuc Khang, Dang Thi Xuan Dung, Lu Nhat Chuong, Nguyen Hoai Thao Tam, Vu Chau Giang, Tran Thi Bich Cam, Huynh Thi Ngoc Anh, Pham Thi Minh Thu, Dinh Nguyen Huy Man, Nguyen Thanh Dung, Nguyen Le Nhu Tung, Huynh Hong Phat, Le Mau Toan, Nguyen Thanh Lam, Pham Nguyen The Nguyen, Hoang Ngoc Nhung, Tran Tan Thanh, Nguyen Van Vinh Chau, Tang Chi Thuong, Guy Thwaites, C. Louise Thwaites, Marc Choisy, and Le Van Tan
Author affiliation: Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam (T. Ong, C.T. Thuy, N.T. Lam, P.N.T. Nguyen, H.N. Nhung, T.T. Thanh, G. Thwaites, C.L. Thwaites, M. Choisy, L.V. Tan); Ho Chi Minh City Center for Disease Control, Ho Chi Minh City (N.H. Tam, L.H. Nga, N.T.V. Uyen, T.T.T. Lan, A. Tran, L.T.K. Diem, H.P. Khang, D.T.X. Dung, L.N. Chuong, N.H.T. Tam, V.C. Giang, T.T.B. Cam, H.T.N. Anh, P.T.M. Thu); Hospital for Tropical Diseases, Ho Chi Minh City (D.N.H. Man, N.T. Dung, N.L.N. Tung, H.H. Phat, L.M. Toan); Department of Health, Ho Chi Minh City (N.V.V. Chau, T.C. Thuong); Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom (G. Thwaites, C.L. Thwaites, M. Choisy, L.V. Tan)

Main Article

Figure 2

Comparison of seroprevalence and vaccination coverage in a study of immunity gap before a measles outbreak, Ho Chi Minh City, Vietnam, 2024. A) Seroprevalence among children receiving first measles vaccine dose only; B) seroprevalence among children receiving first and second measles vaccine doses. Bars show the 95% CI of seroprevalence (vertical) and vaccine coverage (horizontal). Seroprevalence remained below the administrative vaccination coverage estimates for children who received both first and second measles doses but corresponded more closely with second-dose coverage. The blue dashed line indicates 1:1 relationship of vaccination coverage to seroprevalence. A wider view, administrative coverage data for each district and neighboring provinces, and antibody concentration of 17 children <9 months of age is available in the Appendix.

Figure 2. Comparison of seroprevalence and vaccination coverage in a study of immunity gap before a measles outbreak, Ho Chi Minh City, Vietnam, 2024. A) Seroprevalence among children receiving first measles vaccine dose only; B) seroprevalence among children receiving first and second measles vaccine doses. Bars show the 95% CI of seroprevalence (vertical) and vaccine coverage (horizontal). Seroprevalence remained below the administrative vaccination coverage estimates for children who received both first and second measles doses but corresponded more closely with second-dose coverage. The blue dashed line indicates 1:1 relationship of vaccination coverage to seroprevalence. A wider view, administrative coverage data for each district and neighboring provinces, and antibody concentration of 17 children <9 months of age is available in the Appendix.

Main Article

Page created: September 06, 2025
Page updated: September 25, 2025
Page reviewed: September 25, 2025
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