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Novel Highly Pathogenic Avian Influenza A(H5N1) Virus, Argentina, 2025
Ralph E.T. Vanstreels, Martha I. Nelson, María C. Artuso, Vanina D. Marchione, Luana E. Piccini, Estefania Benedetti, Alvin Crespo-Bellido, Agostina Pierdomenico, Thorsten Wolff, Marcela M. Uhart, and Agustina Rimondi
Author affiliation: University of California Davis School of Veterinary Medicine, Davis, California, USA (R.E.T. Vanstreels, M.M. Uhart); National Institutes of Health, Bethesda, Maryland, USA (M.I. Nelson, A. Crespo-Bellido); Servicio Nacional de Sanidad y Calidad Agroalimentaria, Martínez, Buenos Aires, Argentina (M.C. Artuso, V.D. Marchione, L.E. Piccini); Instituto Nacional de Enfermedades Infecciosas Dr. Carlos G. Malbrán, Buenos Aires, Argentina (E. Benedetti); Servicio Nacional de Sanidad y Calidad Agroalimentaria, Buenos Aires, Argentina (A. Pierdomenico); Robert Koch-Institut, Berlin, Germany (T. Wolff, A. Rimondi)
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Figure 2

Figure 2. Key reassortment and migration events leading to the novel triple reassortant influenza A(H5N1) viruses in February 2025, Argentina. Each box represents 1 of the 8 segments of the influenza A virus genome, numbered in order of longest to shortest length: 1, polymerase basic2; 2, polymerase basic 1; 3, polymerase acidic; 4, hemaggultinin; 5, nucleoprotein; 6, neuraminidase; 7, matrix protein; and 8, nonstructural protein. Curved black arrows indicate the direction of major geographic migration events. Straight black arrows indicate sequential reassortment events of interest. LPAI, low pathogenicity avian influenza.
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Page created: November 17, 2025
Page updated: December 12, 2025
Page reviewed: December 12, 2025
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