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Volume 31, Number 12—December 2025

Dispatch

Bat Reovirus as Cause of Acute Respiratory Disease and Encephalitis in Humans, Bangladesh, 2022–2023

Sharmin Sultana1, Ariful Islam1, James Ng, Sunil Kumar Dubey, Manjur Hossain Khan, Cheng Guo, Mohammed Ziaur Rahman, Joel M. Montgomery, Syed Moinuddin Satter, Tahmina Shirin, W. Ian Lipkin, Lisa Hensley2, and Nischay Mishra2Comments to Author 
Author affiliation: Institute of Epidemiology, Disease Control and Research (IEDCR), Dhaka, Bangladesh (S. Sultana, A. Islam, M. Hossain Khan, T. Shirin); Gulbali Research Institute, Charles Sturt University, Wagga Wagga, New South Wales, Australia (A. Islam); Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA (J. Ng, S. Kumar Dubey, C. Guo, W.I. Lipkin, N. Mishra);icddr,b, Dhaka (M.Z. Rahman, S. Moinuddin Satter); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.M. Montgomery); National Bio- and Agro-defense Facility, Agricultural Research Service, US Department of Agriculture, Manhattan, Kansas, USA (L. Hensley)

Main Article

Figure 3

Comparitive phylogeny of bat reovirus as cause of acute respiratory disease and encephalitis in humans, Bangladesh, 2022–2023. A) S1 segment phylogeny showing 96.7%–99.9% average nucleotide identity (ANI) with each other (BDB051, BDB113, and BDB047) and clustered with Indonesia/2010, NBV-Australia, NBV-Nachunsulwe-57, and Kasama virus. B, C) Phylogeny of S2 (B) and S3 (C) segments showing partial consistency with S1 segments. D) S4 segments clustered with Kampar and Melaka strains, previously linked to mild respiratory illness in humans and reported human-to-human transmission. GenBank accession numbers are indicated. Scale bars indicate nucleotide substitutions per site.

Figure 3. Comparitive phylogeny of bat reovirus as cause of acute respiratory disease and encephalitis in humans, Bangladesh, 2022–2023. A) S1 segment phylogeny showing 96.7%–99.9% average nucleotide identity (ANI) with each other (BDB051, BDB113, and BDB047) and clustered with Indonesia/2010, NBV-Australia, NBV-Nachunsulwe-57, and Kasama virus. B, C) Phylogeny of S2 (B) and S3 (C) segments showing partial consistency with S1 segments. D) S4 segments clustered with Kampar and Melaka strains, previously linked to mild respiratory illness in humans and reported human-to-human transmission. GenBank accession numbers are indicated. Scale bars indicate nucleotide substitutions per site.

Main Article

1These first authors contributed equally to this article.

2These last authors contributed equally to this article.

Page created: November 24, 2025
Page updated: December 23, 2025
Page reviewed: December 23, 2025
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