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Volume 31, Number 2—February 2025
CME ACTIVITY - Research

Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England

Matthew A. Davies1, Brechje de Gier1, Rebecca L. Guy, Juliana Coelho, Alje P. van Dam, Robin van Houdt, Sébastien Matamoros, Marit van den Berg, Patrick E. Habermehl, Kartyk Moganeradj, Yan Ryan, Steve Platt, Henry Hearn, Eleanor Blakey, Darren Chooneea, Bart J.M. Vlaminckx, Theresa Lamagni, and Nina M. van SorgeComments to Author 
Author affiliation: Amsterdam University Medical Center, Amsterdam, the Netherlands (M.A. Davies, A.P. van Dam, R. van Houdt, S. Matamoros, M. van den Berg, P.E. Habermehl, N.M. van Sorge); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (B. de Gier); UK Health Security Agency, London, UK (R.L. Guy, J. Coelho, K. Moganeradj, Y. Ryan, S. Platt, H. Hearn, E. Blakey, D. Chooneea, T. Lamagni); University Medical Center Utrecht, Utrecht, the Netherlands (B.J.M. Vlaminckx)

Main Article

Table 2

Characteristics of patients with invasive group A Streptococcus infection caused by emm3.93 or other emm types according to whether all-cause death was recorded within 7 days of diagnosis, November 1, 2023–March 31, 2024, England*

Characteristics
 Died within 7 days, no. (%)
 Alive at 7 days, no. (%)
 aOR (95% Cl)
 p value
No. patients 159 1,132
emm type
Other 127 (12.0) 932 (88.0) Referent
emm3.93
 32 (13.8)
 200 (86.2)
 1.2 (0.8–1.8)
 0.501
Age group, y
0–17 11 (5.7) 182 (94.3) 0.3 (0.1–0.5) <0.0001
18–44 10 (3.5) 276 (96.5) 0.2 (0.1–0.3) <0.0001
45–64 42 (14.4) 250 (85.6) 0.7 (0.5–1.1) 0.146
>65+
 96 (18.5)
 424 (82.5)
 Referent
Sex
M 77 (10.6) 651 (89.4) Referent
F
 82 (14.6)
 481 (85.4)
 1.4 (1.0–2.0)
 0.045
Month
2023 Nov 24 (11.4) 187 (88.6) Referent
2023 Dec 32 (12.8) 218 (87.2) 1.1 (0.6–2.0) 0.663
2024 Jan 44 (14.9) 251 (85.1) 1.3 (0.8–2.3) 0.339
2024 Feb 34 (12.6) 237 (87.4) 1.2 (0.7–2.1) 0.583
2024 Mar 25 (9.5) 239 (90.5) 0.8 (0.4–1.5) 0.503

*Odds ratios for emm type, age group, se,x and month are derived from a multivariable model containing these 4 variables. aOR, adjusted odds ratio.

Main Article

1These authors contributed equally.

Page created: December 30, 2024
Page updated: February 24, 2025
Page reviewed: February 24, 2025
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