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Volume 31, Number 2—February 2025
Research

Short-Lived Neutralizing Antibody Responses to Monkeypox Virus in Smallpox Vaccine–Naive Persons after JYNNEOS Vaccination

Kara Phipps, Jennifer Yates, Jessica Pettit, Sean Bialosuknia, Danielle Hunt, Alan P. DuPuis, Anne Payne, William Lee, and Kathleen A. McDonoughComments to Author 
Author affiliation: Wadsworth Center, New York State Department of Health, Albany, New York, USA (K. Phipps, J. Yates, J. Pettit, S. Bialosuknia, D. Hunt, A.P. DuPuis II, A. Payne, W. Lee, K.A. McDonough); University at Albany, Albany (J. Yates, K.A. McDonough)

Main Article

Figure 1

IgG reactivity to orthopoxvirus antigens in JYNNEOS vaccinees with and without prior smallpox vaccination in a study to assess neutralizing antibody responses to MPXV in smallpox vaccine–naive persons after JYNNEOS vaccination. We analyzed serum specimens from 8 JYNNEOS vaccine recipients for IgG reactivity to recombinant protein antigens derived from MPXV or VACV by using multiplex microsphere immunoassay. One donor who received ACAM2000 vaccine before JYNNEOS vaccine is shown separately in panels A and B. Means of 7 persons who had no prior smallpox vaccination are shown in panels C and D. We plotted mean index values (MFI/cutoff) of MPXV E8 (gray squares), MPXV A35 (blue triangles), and MPXV H3 (white diamonds) for days 0, 8, 26, 56, 118, 231, and 434 postvaccination (panels A, C). We plotted mean index values (MFI/cutoff) of VACV L1 (white circles), VACV A33 (orange triangles), and VACV B5 (gray circles) for days 0, 8, 26, 56, 118, 231, and 434 postvaccination (panels B, D). The horizontal black dashed line at y = 1.0 indicates the cutoff value. The vertical dotted line indicates the second dose of vaccine at day 28 postvaccination. MFI, mean fluorescence intensity; MPXV, monkeypox virus; VACV, vaccinia virus.

Figure 1. IgG reactivity to orthopoxvirus antigens in JYNNEOS vaccinees with and without prior smallpox vaccination in a study to assess neutralizing antibody responses to MPXV in smallpox vaccine–naive persons after JYNNEOS vaccination. We analyzed serum specimens from 8 JYNNEOS vaccine recipients for IgG reactivity to recombinant protein antigens derived from MPXV or VACV by using multiplex microsphere immunoassay. One donor who received ACAM2000 vaccine before JYNNEOS vaccine is shown separately in panels A and B. Means of 7 persons who had no prior smallpox vaccination are shown in panels C and D. We plotted mean index values (MFI/cutoff) of MPXV E8 (gray squares), MPXV A35 (blue triangles), and MPXV H3 (white diamonds) for days 0, 8, 26, 56, 118, 231, and 434 postvaccination (panels A, C). We plotted mean index values (MFI/cutoff) of VACV L1 (white circles), VACV A33 (orange triangles), and VACV B5 (gray circles) for days 0, 8, 26, 56, 118, 231, and 434 postvaccination (panels B, D). The horizontal black dashed line at y = 1.0 indicates the cutoff value. The vertical dotted line indicates the second dose of vaccine at day 28 postvaccination. MFI, mean fluorescence intensity; MPXV, monkeypox virus; VACV, vaccinia virus.

Main Article

Page created: December 11, 2024
Page updated: January 10, 2025
Page reviewed: January 10, 2025
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